ID A0A011ALU5_9ACTN Unreviewed; 889 AA.
AC A0A011ALU5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Glycine cleavage system T protein (Aminomethyltransferase) {ECO:0000313|EMBL:EXG82916.1};
GN ORFNames=CryarDRAFT_4120 {ECO:0000313|EMBL:EXG82916.1};
OS Cryptosporangium arvum DSM 44712.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=927661 {ECO:0000313|EMBL:EXG82916.1, ECO:0000313|Proteomes:UP000021053};
RN [1] {ECO:0000313|EMBL:EXG82916.1, ECO:0000313|Proteomes:UP000021053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44712 {ECO:0000313|EMBL:EXG82916.1,
RC ECO:0000313|Proteomes:UP000021053};
RG DOE Joint Genome Institute;
RA Eisen J., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXG82916.1}.
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DR EMBL; JFBT01000001; EXG82916.1; -; Genomic_DNA.
DR RefSeq; WP_051570705.1; NZ_KK073874.1.
DR AlphaFoldDB; A0A011ALU5; -.
DR PATRIC; fig|927661.3.peg.4093; -.
DR HOGENOM; CLU_011963_0_0_11; -.
DR OrthoDB; 5287468at2; -.
DR Proteomes; UP000021053; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.10.20.440; 2Fe-2S iron-sulphur cluster binding domain, sarcosine oxidase, alpha subunit, N-terminal domain; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR042204; 2Fe-2S-bd_N.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR041117; SoxA_A3.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF17806; SO_alpha_A3; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:EXG82916.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000021053};
KW Transferase {ECO:0000313|EMBL:EXG82916.1}.
FT DOMAIN 118..362
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 410..491
FT /note="SoxA A3"
FT /evidence="ECO:0000259|Pfam:PF17806"
FT DOMAIN 506..772
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 797..881
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 889 AA; 95776 MW; EC014C90C23736B9 CRC64;
MRARTGGRID RGRTLTFTFD GETYTGHPGD TLASALLAAG RHTIARSITF GRPRGITAAW
AEDSGGPVQI EEPFPEPMRP ATTVELYDGL SARSLAGRGR LADVPDTARY DAKHHHVDVL
VVGAGPAGLA AARDAARAGD RVALVDEQSE AGGSLLSEPE TPGWVADTVA ELAAHPDVLH
LQRTTAFGTY DDGFVLALER RTDHLGAAAP KNVSRQRVWR LRARRIVVAT GAHERPIVFA
DNDRPGIMLA GAARTFLNRY GVLPGRAAVV FTTNDSAYDA AFDLHRAGVR VRAIVDARTE
IPAHLAEACD RARIWLVRGA VVTGTRGEDR ITHALVGPDP IACDLLLVSG GWNPAVHLFS
QARGRLRYDG TLGAFVPGEP VDGLTVIGSA AGEVVASKTL WRVPGPAEFQ FVDLQRDATV
ADLRHAVGAG LRSIEHIKRF TTIGTAHDQG KTSGVLTTGI VAELLGVPVE AVGTTTFRPP
YTPVAFAALA GRDRGHLFDP ERYTALHDWH VAAGAVFEDV GQWKRPRYYP RPGEDMPAAV
LRECAAARTG VGLLDGSTLG KIDVRGPDAG VLLDRLYTNL MSSLKPGMVR YGVMCGVDGM
VIDDGTVLRL ADDHFLVMTT TGGAAKILDW MEEWLQTEWP ELRVHLTSVT DHWATFPVVG
PRSRDVVGAV FPDVDVSREA FPFLAIRETT LDGVPVRLAR ISFSGELAYE VYVSSWYAVA
IWQRLLDAGR PHGLTPYGTE TMHVLRAEKG YPIIGQDTDG TVTPQDLGMA WVVSKKKADF
VGKRSFARAA NLDPLRKHLV GLLPLDRRTV LPEGSQIVER LTEPPVAMLG HVTSSYRSAE
LGRPFALALV KGGRERVGEV LQVPVDGTLV PVEVTGPVLV DPEGARRDG
//
