ID A0A011MGF9_9PROT Unreviewed; 294 AA.
AC A0A011MGF9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:EXI68933.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:EXI68933.1};
GN Name=glxR_2 {ECO:0000313|EMBL:EXI68933.1};
GN ORFNames=AW08_00759 {ECO:0000313|EMBL:EXI68933.1};
OS Candidatus Accumulibacter adjunctus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1454001 {ECO:0000313|EMBL:EXI68933.1, ECO:0000313|Proteomes:UP000020218};
RN [1] {ECO:0000313|EMBL:EXI68933.1, ECO:0000313|Proteomes:UP000020218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-12 {ECO:0000313|Proteomes:UP000020218};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXI68933.1}.
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DR EMBL; JFAX01000003; EXI68933.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A011MGF9; -.
DR STRING; 1454001.AW08_00759; -.
DR PATRIC; fig|1454001.3.peg.703; -.
DR Proteomes; UP000020218; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EXI68933.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000020218}.
FT DOMAIN 3..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 294 AA; 29810 MW; 8EF138D71A9F44CD CRC64;
MRLGFIGCGV MGRPMALNLL RAGHRLAFWA RRPEAAQPLL AAGAVACVSP AAVASAAEVV
FTAVTADADV EQVVFAPDGL AEGFAAGAVL VDMSTIAPQA ARSIAGRLVR LGVAMLDAPV
SGGGQGAIDA SLSIMVGGQA AVLERVRPLL ELLGSTIVHV GDHGAGQVAK ACNQMLMVAT
IQAVAEALHL SRAAGVDPAR VHAALAGGSA ASRVLQAMGG RMVARDFAAG VEARLHHKDY
AVLIAEAHRL GLPLPVSAQV CQQLNALMAL GWGRCDTASL LRVLEAGPLA TGSH
//
