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Database: UniProt
Entry: A0A011NDL5_9PROT
LinkDB: A0A011NDL5_9PROT
Original site: A0A011NDL5_9PROT 
ID   A0A011NDL5_9PROT        Unreviewed;       359 AA.
AC   A0A011NDL5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   03-JUL-2019, entry version 23.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG {ECO:0000313|EMBL:EXI73231.1};
GN   ORFNames=AW07_02845 {ECO:0000313|EMBL:EXI73231.1};
OS   Candidatus Accumulibacter sp. SK-11.
OC   Bacteria; Proteobacteria; Betaproteobacteria;
OC   Candidatus Accumulibacter.
OX   NCBI_TaxID=1454000 {ECO:0000313|EMBL:EXI73231.1, ECO:0000313|Proteomes:UP000020226};
RN   [1] {ECO:0000313|EMBL:EXI73231.1, ECO:0000313|Proteomes:UP000020226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK-11 {ECO:0000313|Proteomes:UP000020226};
RA   Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT   "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT   clades.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EXI73231.1}.
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DR   EMBL; JFAW01000017; EXI73231.1; -; Genomic_DNA.
DR   PATRIC; fig|1454000.3.peg.2361; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000020226; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000020226};
KW   Reference proteome {ECO:0000313|Proteomes:UP000020226};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:EXI73231.1}.
FT   DOMAIN       45    341       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   359 AA;  39303 MW;  B23816B3FB2B5BFE CRC64;
     MTLQSKPNTD DVRIREIKEL VPPAHVFREF PVGVRAALTT YNTRQSIHRI LHGADTRLLV
     VVGPCSIHDV DSAIEYARRL QAQVARFQDD LLLVMRVYFE KPRTTVGWKG LINDPRLDNS
     FRINEGLRLA RGLLLEINDM GLPCATEFLD TITPQYTADL IAWGAIGART TESQVHRELA
     SGLSCPVGFK NGTDGNXXIA IDAIRAAQSP HHFLSVTKAG HSAIVSTGGN EDCHVILRGG
     REPNHDAAHV DAACREIAAA GLAARLMIDA SHANSNKRFK QQIEVARDVA SQVAGGDQRV
     IGMMLESHLN EGRQDLAPGQ PLEYGRSITD ACLGWEDSLT VLEILAKGVR DRRLVEAAQ
//
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