ID A0A011NJS5_9PROT Unreviewed; 542 AA.
AC A0A011NJS5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase {ECO:0000313|EMBL:EXI64857.1};
DE EC=4.2.1.120 {ECO:0000313|EMBL:EXI64857.1};
GN Name=abfD {ECO:0000313|EMBL:EXI64857.1};
GN ORFNames=AW08_03605 {ECO:0000313|EMBL:EXI64857.1};
OS Candidatus Accumulibacter adjunctus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1454001 {ECO:0000313|EMBL:EXI64857.1, ECO:0000313|Proteomes:UP000020218};
RN [1] {ECO:0000313|EMBL:EXI64857.1, ECO:0000313|Proteomes:UP000020218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-12 {ECO:0000313|Proteomes:UP000020218};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXI64857.1}.
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DR EMBL; JFAX01000032; EXI64857.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A011NJS5; -.
DR STRING; 1454001.AW08_03605; -.
DR PATRIC; fig|1454001.3.peg.3642; -.
DR Proteomes; UP000020218; Unassembled WGS sequence.
DR GO; GO:0043721; F:4-hydroxybutanoyl-CoA dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:EXI64857.1};
KW Lyase {ECO:0000313|EMBL:EXI64857.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000020218}.
FT DOMAIN 12..279
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 288..487
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 197
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 542 AA; 58519 MW; E57339A03C40BDF9 CRC64;
MNATRPAGLM SGSDYRESLR RYRPTVYLDG HRLDSVADSR ELRPGINALA VTYDFAHDPR
QAPLMTALQT SRGRTVNRML HIDESAADLL NKLEAVRLLC QETGCAQRYL AHDALNAINQ
LCARADAAAG SNERRARFAA YLEHVQDGDL ALGIAMTDAK GDRSQRPHRQ ASRNSYVHIV
ERLAAGVVIS GTKAIVTGAP YMHEILVMPS RNMGPADADF AICCALPVDA AGLTMIARPA
GRPGEKLEHG AAPFSRRYGQ STAVLVFDRV FVPWDRVFLA GEWEHSASLT YAYATHHRHS
CIAARAGFGD LLIGAGALMC EANGFDPGTK ASLREPMVEL IKITEGFFAC GVAASVYGAA
DPHSGSFMPE PVFANIGKLL LATQIYDMHR LAHEVSGGLI VALPGPDEDH NPATAATLAE
VLRASPDVPY DRRIEVARFI EDLTASYQGG WYSVISLHGG GSPAAMKREI WRNYPLGSKV
ELVERLLERG VLHDESRPIT RNRQPGRCCA AGCALPGQAM MVALPAAAGC HPTPVDEEPA
AE
//
