ID A0A011QVC9_9PROT Unreviewed; 832 AA.
AC A0A011QVC9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Methylmalonyl-CoA mutase {ECO:0000313|EMBL:EXI93110.1};
DE EC=5.4.99.2 {ECO:0000313|EMBL:EXI93110.1};
GN Name=scpA_1 {ECO:0000313|EMBL:EXI93110.1};
GN ORFNames=AW12_00072 {ECO:0000313|EMBL:EXI93110.1};
OS Candidatus Accumulibacter sp. BA-94.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1454005 {ECO:0000313|EMBL:EXI93110.1, ECO:0000313|Proteomes:UP000020878};
RN [1] {ECO:0000313|EMBL:EXI93110.1, ECO:0000313|Proteomes:UP000020878}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BA-94 {ECO:0000313|Proteomes:UP000020878};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXI93110.1}.
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DR EMBL; JEMZ01000003; EXI93110.1; -; Genomic_DNA.
DR STRING; 1454005.AW12_00072; -.
DR Proteomes; UP000020878; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF3; COENZYME B12-DEPENDENT MUTASE; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00022628};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EXI93110.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000020878}.
FT DOMAIN 533..662
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT REGION 792..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 90570 MW; C9D3D5AFCC0E9FAD CRC64;
MVAPRKNRDQ PWLMRTYSGH SSAKASNALY RTNLAKGQTG LSVAFDLPTQ TGYDADSPLA
RGEVGKVGVP ISSIEDMDQL FDQIPLDQMN TSMTINATAA WLLSLYIGLA QRRGIDPKKL
SGTTQNDIIK EYLSRGTYIY PPGPSMRLIA DTINYTIRHV PKWNPTNVCS YHLQEAGATP
VQELAYALCT AMAVLDRVKA SGEIGPDEFP LVVERISFFV NAGIRFIEEC CKLRAFGEMW
DELTLSRYQV EDPKLRRFRY GVQVNSLGLT EAQPENNVQR IVLEMLAVAL SKRARARAIQ
LPAWNEAMGL PRPWDQQWAL RIQQVMAFET DLLEYGDIFD GSPVIAAKVA ELVEGARREI
DNVEAQGGII AAIESGYIKR ELVGSHMSRL RAIESGELKI IGLNCFHETA ESPLTAGSDG
AIMKSDPAAE RQQIERLQEH RRQRSDADVR AALQGLADAA RSGDNIMPSS IRCALAGVTT
GEWGDSLRAV FGEFRPPTGV DIAIDSREVL GRKDQVTELR ERVGRTGNAL GRPLKILVGK
PGLDGHSNGA EQVAVKARDV GFEVVYDGIR LTPQQIAQAA QEEGVHVVGL SILSGSHMEL
VGSVLQELRA RDLAALPVVA GGIIPPADAE RLLALGVRAI YTPKDFNLNA IMGDIVDVVR
ENNGLERLGS LSCGSARCLE RYMTNLGLPD PEQLAARILR GERSAVASGL NLLDNRLPAA
RGRAVRLLAC LSGERWLSAG HLIGVTGPPG AGKSSLVSAM IREWRLAXXX XXXXARRSAC
WRSTRRAGPS WAVARSSATA SASRPRRRTR VSSSARSPIA TSWVGLPARS GR
//