ID A0A011UFZ4_RUMAL Unreviewed; 905 AA.
AC A0A011UFZ4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=RASY3_06725 {ECO:0000313|EMBL:EXM39559.1};
OS Ruminococcus albus SY3.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1341156 {ECO:0000313|EMBL:EXM39559.1, ECO:0000313|Proteomes:UP000021369};
RN [1] {ECO:0000313|EMBL:EXM39559.1, ECO:0000313|Proteomes:UP000021369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY3 {ECO:0000313|EMBL:EXM39559.1,
RC ECO:0000313|Proteomes:UP000021369};
RA Dassa B., Borovok I., Lamed R., Flint H., Yeoman C.J., White B.,
RA Bayer E.A.;
RT "Rumen cellulosomics: divergent fiber-degrading strategies revealed by
RT comparative genome-wide analysis of six Ruminococcal strains.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXM39559.1}.
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DR EMBL; JEOB01000002; EXM39559.1; -; Genomic_DNA.
DR RefSeq; WP_037286291.1; NZ_JEOB01000002.1.
DR AlphaFoldDB; A0A011UFZ4; -.
DR PATRIC; fig|1341156.4.peg.1763; -.
DR OrthoDB; 9804734at2; -.
DR Proteomes; UP000021369; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:1990362; F:butanol dehydrogenase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044731; BDH-like.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR43633; ALCOHOL DEHYDROGENASE YQHD; 1.
DR PANTHER; PTHR43633:SF1; ALCOHOL DEHYDROGENASE YQHD; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000021369}.
FT DOMAIN 13..314
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 461..852
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 905 AA; 98148 MW; 1084687BC2941ACA CRC64;
MAKKEYEIVD GVEKLEAALE RVRAAQRKMA TFTQEQVDRI FLAAATAANR ARIDLAEQAV
AETGMGIVED KVIKNHYASE YIYNKYRDTK TCGVLEEDKS AGIKKIAEPI GVIGAVIPTT
NPTSTAIFKS LIALKTRNGI IISPHPRAKE STIAAAKVVL EAAVEAGAPE DIIAWIDIPS
LEMTNMLMKE VDIILATGGP GMVHAAYSSG KPALGVGAGN TPAIIDDSAD ILLAVNSIIH
SKTFDNGMIC ASEQSVIVLD SIYDAVKTEF AARGCYFLKP DELNKVRKTI IINGALNAKI
VGQSAAKIAE LAGVTVPEGS KILIGEVESV DISEEFAHEK LSPVLAMYKA SDIQDAFGKA
EHLIADGGYG HTASIYLDAV REQEKLSEFG ERMKTCRILV NTPSSQGGIG DLYNFKLAPS
LTLGCGSWGG NSVSENVGVK HLLNIKTVAE RRENMLWFRA PEKVYFKKGC LPVALDELKN
VMGKKKAFIV TDSFLFKNGF TKPVTDKLDE MGIVHETFSD VAPDPTLACA VEGVKAIRSF
EPDVIIAIGG GSAMDAAKIM WVMYEHPEAD FMDMAMRFVD IRKRIYTFPK MGEKAYFICV
PTSSGTGSEV TPFAVITDDK TGHKYPLADY ELMPNMAIVD TDMMMSAPKG LTAASGLDCM
VHDLEALVSV MATPFTDGIA LESLKMTFDN LPECVENGQT AVRARENMAH AATMAGMAFA
NAFLGIGHSL AHKLGAYHHL PHGICCALVI SEVIRFNASD VPVKMGTFPQ YEYPQAAAKY
ARIARYLGVQ GSGDNELVEG LIAKIEELKE AVGCKKTIAE YGISEEDFLA TLDKMSRDAF
DDQCTGANPR YPLISELKQI YMNVYYGRTF TETEKPDASQ IDSAESSKDF KQAFNRAVSS
GKKRV
//
