ID   A0A014NLH8_9BURK        Unreviewed;       665 AA.
AC   A0A014NLH8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Protein-disulfide reductase {ECO:0000313|EMBL:EXU80318.1};
GN   ORFNames=AX13_17245 {ECO:0000313|EMBL:EXU80318.1};
OS   Comamonas aquatica DA1877.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=1457173 {ECO:0000313|EMBL:EXU80318.1, ECO:0000313|Proteomes:UP000020766};
RN   [1] {ECO:0000313|EMBL:EXU80318.1, ECO:0000313|Proteomes:UP000020766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DA1877 {ECO:0000313|EMBL:EXU80318.1,
RC   ECO:0000313|Proteomes:UP000020766};
RA   Watson E., Macneil L.T., Ritter A.D., Yilmaz L.S., Rosebrock A.P.,
RA   Caudy A.A., Walhout A.J.;
RT   "Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans
RT   Gene Expression and Life History Traits.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXU80318.1}.
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DR   EMBL; JBOK01000008; EXU80318.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A014NLH8; -.
DR   STRING; 225991.MA05_00400; -.
DR   PATRIC; fig|1457173.3.peg.1696; -.
DR   Proteomes; UP000020766; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProt.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR   CDD; cd02953; DsbDgamma; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR003834; Cyt_c_assmbl_TM_dom.
DR   InterPro; IPR035671; DsbD_gamma.
DR   InterPro; IPR028250; DsbDN.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR32234:SF3; SUPPRESSION OF COPPER SENSITIVITY PROTEIN; 1.
DR   PANTHER; PTHR32234; THIOL:DISULFIDE INTERCHANGE PROTEIN DSBD; 1.
DR   Pfam; PF02683; DsbD; 1.
DR   Pfam; PF11412; DsbD_N; 1.
DR   Pfam; PF13899; Thioredoxin_7; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Redox-active center {ECO:0000256|ARBA:ARBA00023284};
KW   Reference proteome {ECO:0000313|Proteomes:UP000020766};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        269..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        491..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        519..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          538..665
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
SQ   SEQUENCE   665 AA;  69930 MW;  B917ECA0F9AF3128 CRC64;
     MVTPRVRAQL VALAPEGIAP GRPLALGLRI EHQPDWHTYW KNAGDSGLPT QLTWQLPAGL
     HAGEIAWPVP QQIRVGDMLN YGYEGTVLLP VPLQVAPDFA PGSDGGVDIR LHASWLVCRV
     ECIPEEGNFL MRLPASAPQT LWSAAFEAAH AQAPLALDTA QASASASDGG ERLQLRVAGL
     PQAAHGQTLA LYPETADTLV HAAVLGQDWH QRWDGAVWTA DVPLSPMRGE APPQLASVSP
     ALAAALAANQ QAAATLPAPP APSASTATWL LAVLGGLVGG LLLNLMPCVF PVLAIKVMGF
     ARHGTDTAAQ RRHGLAYAAG VVLSFLALGG VLLGLRAAGE QLGWGFQLQS PAVVAALAAL
     FTLIGLNLAG VFEFGHVLPS RVANLHARHP LGDAFLSGVV AVAIASPCTA PFMGASLGFA
     VGLPAVQALS VFAALGVGMA LPYVLVSWVP ALLRWLPRPG AWMDTFRRAM AFPMFATVIW
     LVWVIGQQTG IDGAATLLAL LLCLAALAWT LTLRGRTRAV LALLVLALAG WLAHSLGRNL
     LEPAPVATAT SARDTWQPWS PDAQAALLTA GRPVFVDYTA AWCVTCQVNK RTTLADAEVL
     ADFARRNVAL LRADWTRRDP AITQALAALG RNGVPVYVLL APGQPPVVLT ELLSRQEVHT
     ALAQL
//