ID A0A014PMZ3_9HYPO Unreviewed; 5433 AA.
AC A0A014PMZ3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Nonribosomal peptide synthetase PesA {ECO:0000313|EMBL:EXU98277.1};
GN ORFNames=X797_008667 {ECO:0000313|EMBL:EXU98277.1};
OS Metarhizium robertsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=568076 {ECO:0000313|EMBL:EXU98277.1, ECO:0000313|Proteomes:UP000030151};
RN [1] {ECO:0000313|EMBL:EXU98277.1, ECO:0000313|Proteomes:UP000030151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2575 {ECO:0000313|EMBL:EXU98277.1,
RC ECO:0000313|Proteomes:UP000030151};
RA Giuliano Garisto Donzelli B., Roe B.A., Macmil S.L., Krasnoff S.B.,
RA Gibson D.M.;
RT "The genome sequence of the entomopathogenic fungus Metarhizium robertsii
RT ARSEF 2575.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ANH22637.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189621; DOI=10.1186/s12864-016-2710-6;
RA Agrawal Y., Narwani T., Subramanian S.;
RT "Genome sequence and comparative analysis of clavicipitaceous insect-
RT pathogenic fungus Aschersonia badia with Metarhizium spp.";
RL BMC Genomics 17:367-367(2016).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KU202726; ANH22637.1; -; Genomic_DNA.
DR EMBL; JELW01000028; EXU98277.1; -; Genomic_DNA.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_0_1; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000030151; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 4.
DR CDD; cd19542; CT_NRPS-like; 2.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 13.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 782..858
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2319..2395
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3394..3470
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4449..4523
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 5348..5371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5353..5367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5433 AA; 603870 MW; 186FEF1020C8CF0B CRC64;
MAPAGETLLL KSTDFQETGS VHTAVSHTED IHALQGQRQS VNVAWSHNAE SLQRFCHENE
FQLPTVFKAA WGLVLGKYLG LDHVVFSSLV QDGTIDAAPA SCQLLLDESV SILSLLRNLE
LQTKTLDVEK TSRTGDNSPL SDSQLVFQVH QPGKVVAALN RSSQSTGNIV LLVQVSDNML
NITLSYSTST LIEEEAVNIG ATFAKAASLI VLNPNQKLHD LDLISDRDLA SIWGWNEPQP
RVIDSCVHHI IQSRVEQQPD ALAICGWDAS ITYRQLDDYS NRLAHHLLGF GVGPEVIVPL
CFEKSAWAIV ALLGVVKAGG AFVFIDPSHP KGRRDDIISQ IASTLVLTSI AQADQWTDSS
LEVVPLGPQL VDALAPQTQP PVTTVCPNNI LYVIFTSGST GRPKACVVEH SSFCSGAVAQ
AEVANMDSSS RVLQLASFSF DVSLLEIMTA LMHGACICMP SAASMNEGVA KLINKFQITW
AFLTPSLVKV IDPRDVPDLK TLILGGEALS KSDIDTWAEH VQLGNGYGPS ECSVAAAGNP
NLTPSTSPSN IGRAVGGLCW IVNAEDHNKL VPVGCVGELL IEGPIVARGY LNAPEKTAEV
FITGPDWGPL TRQGAPRRLY KTGDLARYNP DGTIHFIGRK DTQVKLRGLR IELGEIEHHI
SVHGFTQHAI VILPKSGPCK ERLVVALSLK DFLPDTSKTS NVRLIPEEAQ ERASKQVADI
KEQLSRHVPH YMVPETWIVV EAIPLMLSGK MARSQVSKWI AEMDDETYDR AVGVHSQGEG
ATEMTEHEIQ LQLVYSDVLN LALSRIPLDR SFLSLGGDSI SAMQVVSRCR SRGMAVTVKD
IIALKGISEL ALRVVRVANS AHDQEESFDT PFALSPVQRM YVATTHLASN GSSTRYNQSF
FLTVTRQTAD EELRKGFQMV VAKHSMLRAR FIESQDGTWQ QVVLKQVEGT YNVVLHNVTA
VEDIDAIIED AQSSLDLIRG PVFAAHVFNV KSQGQFLFLV AHHAIIDLVS WRVVMKDLED
AVTSGEIANH VSLPYQKWLQ LQADNARDHG SPGEVLPFNV TPPDMQYWGM QHQKNYISDT
SEDTVKLSLD LTESLMGSQC HTALRTEPID LILSILMYSF AHVFNDRATP PFFRESHGRE
SWTDEIDISE TVGWFTTMFP LCTSATFEDD IVEFTRQIKD NRHAIPANGR PYFASRFLNQ
EGMEAFADHS QVEICFDYLG LYQQLEKSDA LLRQEPRTMT ANTSDIGPNV RRFALIEITA
EMINNQMQFS FVYNHNMKHM PKLKEWIASL PDSFSECIDQ LSNARIQHTL SDFPMIKMSY
EGLERLSNDI LPQTGISFEQ VQDIYPCSPM QQGLLISQSK STGVYKYCHT AEIISRSANS
VDLDRLSSAW EKVVQRHSVL RTIFIPSVGT EGVYDQVVLK HYRGRVSIFH DDGVDSGNKF
KNQAPIEFTD TEPPNRLSLC QTNEGRVFCQ FEFNHAIIDG GSMPIILQDF ILAYDGRTPD
RPAALFQEYI SYLRSLPKGP GLSYWMNYLK NIEPTYLPSI QGSSKDPQFL EMEVNINMET
SVLLDFCQQN NLTLSNIFHV AWGLVLRAHT GRNDVCFGYL LSGREAPIRD IERAVGPFIT
MLVSRLGLEN DVPILDILQK VQGDFLLGME HQHCPLADIQ HELGLAGQPL FNTVMSFQKA
QEGAGEDEST ISVVGLEAYD PPEYEVTLDV MVSEADVVTT LGYWTSSIST EQAKNLGLIF
SRAVECIVKN INSTVDDIDL VGGEHMTQIL QWNADLPPAH YHCIHHLFHE QVVKQPDAPA
ICSFDGNFTY AELDDLSTKL AHHLVSMGVG PQVYVPFCFH KSAWTTVVIM AILKAGGACV
PMDPAQPVSR LEAISTMCSA KVAVTAPQNA HLLEGLVDVI ISVDQGFING LPTVAGMPCA
SVQPDNVAYV IFSSGTTGTP KGIQLYHYSL ATFALWNNLI VKGNGPGQRV LQFAAYTFDV
SISDILGSLM FGACICNISD HDRMNNLSQA IRDVKATAID LTATVAALIR PADVPSVRIL
QLGGEALTKE VVDIWAGNLD TLVNVYGPAE CSVTCSYSCN ILDDTDLANI GRVVGGLGWV
VEPNNHDKLA PLGCVGELLI EGAILSAGYF GDAEKTKKSF ICNPIWSRTQ PGVDRRFYKT
GDLVRYNSDG SLHILGRGDT QIKLYGQRLD LTDIEAQIID HQPSLRQVTV EAIMPKGTTR
KTLAAFFVMD DPDDGSTVDS LDSTPISLTP QLQKDLQELQ SSLALSLPRY MIPATYIRMS
QMPMNSSGKT NRAALRTMAA QFSETQWSDY SLENKVKELP STDLEKRLQQ LWSAVLCIDI
DMIGAKDSFF GLGGDSVAAM RLVAAARASN ILISVMNIFK YPNLCDMALT VEIHETITRD
LVELDSFALL EPSSREETIE DCADKCKVDK DCIEDIYPCT PLQEGLMAIS TRLPRAYVAR
MVFKIPSTID LNRFRNAWQQ LISLEPILRT RVILTNTNSV QVVLRQENPW KEGLTLESYL
EKDNGLPIEY GGLLHRLCII DGLGQDSYFI WSVHHALYDG WSQNLLFERV KQLYMGDAIS
KSPSYNRFIH FLAQEDTKSA NKFWKSQLLR EQAPTSFPVL PSPSYKPRAD HVQTLRLPLS
RQKHSTITSA TLIKAAWAMV VSQYSRSDDI ILALTLSGRT APVPGIMKMT GPTITTVPLR
IELPSRNTTV YKYLELVQNQ AMEMMPYEHV GIQSLRRLCL EAEPDYELDL KHLLVIQSLG
EVDGFLDLEL LPTEEDDFNT YALIVQCSVE EENVCIEARY DRDVIETGQM ERMLWQFQHV
LRQLNDESHS STMEGVDLVS PQDLEQLDVW NSQKHESMDI CIHQVIEEQM RSRPVDAPAI
CAWDGELSYQ ELDRLSNGLA THLVDLGVGP EVMVPICFDK SAWTIVTMIA VLKAGGAYVS
LSSAHPLSRL RGIIDDIDAG LILVAPQYAE LFVDVVPRII VVEPSWVTTL PTSISTPSFG
RPDSAAFVVF TSGSTGKPKG VVIEHRSMVT MAHAEGPSMQ FDSNTRTLNF AASTFDVSNS
EVLTTLMFGG CVCVPSETER LNDLTGVINK WKVNWLFLTP AMADLLDPAK VPTLQTLALG
GEAIRQDLVE RWATKVHLIN SYGPSETTIW TSNSHLSPEK RPANIGRGYG AHTWVTDVTD
HNRLAPIGCV GELLVEGPIL ARGYVKNPDI TSAAFIFDPL WAKDGQKEQR RMYKTGDLVK
YNVDGTLDYI GRKDTQVKLR GQRIEPSEIE DHIRQSLPDV QHVAVEIVSK EGHKEDRALA
AFLQLGQKDQ HLVHDTNSDL VPITEDLRKS MLHLQQLLMG SLPPYMVPQL FIMLHQAPTT
SSGKLDRKAM REMASKLSKP QLAPYMLVDV EKVAPATPME KKLQSLWASL LRIDVSAIGA
NDNFFQSGGD SIIAMRLVAE ARASHLPMSV ADIFRFPKLS EMARAIQDVV FTPATDIEPF
SLLRDEHSLD DIIQMAASVC DVKVEAIEDI YPCTALQKGL FSITIRDPGA YIAQKVFQLP
EALDLDRFKR AWQILADMHP ILRTRILDTD LQVVVREEPA WQSASTLQAY LEHDLSENMN
FGRPLCRYAI VEGHFIWTAH HAVYDAWSNQ LLFDQLRGIY DGDEIPKAVP YSKLIEHLEK
IDQSAAMAFW KGQLSGDKPT SFPEARSLTY KPRPNQAFTY SMAVTHNYKS GTLMSSTLQA
AWALAVARHS NSSDVAFAMA LSGRNLSMQG IESVIGPTIT TVPIVMNLDM EQTVADYLGN
TQKQMTEMIP FAHVGLQNLH SLDNYVDLKH LFVIQSAANE DAEGVLGMIP VPYDIAGFDS
YGLVVECVQG TDKVDVEVRF DTAIISHERI QKMLNLFEHL VGQLNQDEYR SLPLKHVSFF
SPQDAEQIAA WNREPPREKN ETMHNLVQAQ VSARPLAPAI LASDGNFTYA ELDSRSTQLA
HHLVQVGVKP EVMVLVCYNK SAWTIVAMLA ILKAGGACVA INPEHPPERL QAIAQDVKAS
IVVTQQQHRH IFQGWNVNVV LPTESLTNKY PATGTFTSAR PENPAFVVFT SGSTGTPKGI
CLEHRALCAS AQAHGKAMRL GTDSRVLQFA AYTFDVSIGE IFTTLIYGGC VCVPTEEERL
NDLAAFINRM QINWAYLTPT VASFLQPADV PTLKTLSLGG EAVTKENVAV WANRVHLINI
YGPAETSIWS TALCGLEPDT PPTNIGYGVG ALMWITEIAN HDHLCPVGCV GELLIEGPIL
ARGYVALDET TRARFITNPA WAKGQGDRRF YKTGDLVKYN FDGTIDYVGR KDTQFKLHGQ
RIESSEIEHH LSTDRHIRHA MILLSKSKSG QQRLTAIISL ESVPPSAARD VPQLIQAESA
QLEVSLIRKK LAESVPGYMV PSIWLVVDHM SMTVSGKLNR LEMTKWVEQM DEDVFATSAD
AEDLEGSHIP ATVMEDKIQK MLCQVLNLQT VRLDRSFLSL GGDSITAMQL RAKCRAEKIE
LSTQHILRAK SISQMALLAK STSETALAHP EILDSSFGLT PIQQMYFEIE SKAEMSHHFH
QSFLLRITKR IGTLQMARAI EKLVGQHSLL RARFSQGENN QWTQRITGDV ADSHRFSMHQ
LARREQMMPL IEASQRAINI TEGPVFCATL FNIGSNDDVG DSHQLLFLCA HHLVIDLVSW
RHILRDLEQL LDSGRLSSPK PPSFQTWATM QAEYAKELLP QDVMPLQIPP ADFGFWGMLN
QANVFEDQLE TSFSLDEETT DKLFGVSNEA LQTEPVDIIL SALIDSFHRV FTDRPTPTIF
SEGHGRESLA PESDAAEIVG WFTTLNPLHV PVMEEEDELK ILAHTKDLRR QVPSSGYPYF
CSRFLSPQGQ QTFGHHTRME VILNYQGRYQ QLERDDALLR PEPLAENEVH KDQGSDMHRF
SLFEISVEVV QGKTRVSFAY NRRMHHQDLI RQWVSESKEC LGTLTSRLSV TELQLTRSSF
PLLSLEDREL SQFQSHLSSL AIRPSQIEAA YPTSPMQESM ISAQQKVPGI YGVRNMYDVI
PGPQAGPVDH CRLMTAWQRV VDRHVSLRTV FVPSVSRKDS FDQVVLHTHT ARISVIECDD
DNVSEKMRSQ EMIGFLEPVP HHRLAIFTTA SKVMCCLDIS HALTDGMSMR LLMRDLYMAY
ESNLQLAPGP MYSDYIAFLQ QQPASQDAIF WRQYLDAVKP CHLPRPDAPL CSEREQRSVH
VHLKEDFAQI QGFCKTYGLT VANLIQSTWG LVLRKYTGCD DAVFGYLTSG RDMPIDGVMD
LVGALIHMLL YRQVVDSATT VLALLQQTRN DFLQSLPHQY GLVPAIKEHT RGAAQGLFNT
IMSMQYSNGA GEESESDDSK EPLLKFENKG GQDPNQYDVS VAVHVDGVSV EISIAYWTDM
MRDGQAAGLA ADFSKTLTAI MAQPKMKIVD LDI
//
