ID A0A014Q9Q3_9BURK Unreviewed; 440 AA.
AC A0A014Q9Q3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=C4-dicarboxylate transport protein {ECO:0000256|HAMAP-Rule:MF_01300};
GN Name=dctA {ECO:0000256|HAMAP-Rule:MF_01300};
GN ORFNames=AX13_02175 {ECO:0000313|EMBL:EXU79927.1};
OS Comamonas aquatica DA1877.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Comamonas.
OX NCBI_TaxID=1457173 {ECO:0000313|EMBL:EXU79927.1, ECO:0000313|Proteomes:UP000020766};
RN [1] {ECO:0000313|EMBL:EXU79927.1, ECO:0000313|Proteomes:UP000020766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DA1877 {ECO:0000313|EMBL:EXU79927.1,
RC ECO:0000313|Proteomes:UP000020766};
RA Watson E., Macneil L.T., Ritter A.D., Yilmaz L.S., Rosebrock A.P.,
RA Caudy A.A., Walhout A.J.;
RT "Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans
RT Gene Expression and Life History Traits.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate across the membrane.
CC {ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01300}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|ARBA:ARBA00006148,
CC ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXU79927.1}.
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DR EMBL; JBOK01000011; EXU79927.1; -; Genomic_DNA.
DR RefSeq; WP_042417696.1; NZ_JBOK01000011.1.
DR AlphaFoldDB; A0A014Q9Q3; -.
DR STRING; 225991.MA05_02935; -.
DR GeneID; 74940079; -.
DR PATRIC; fig|1457173.3.peg.2104; -.
DR Proteomes; UP000020766; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865:SF1; AEROBIC C4-DICARBOXYLATE TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR42865; PROTON/GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01300};
KW Reference proteome {ECO:0000313|Proteomes:UP000020766};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|HAMAP-Rule:MF_01300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01300}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 160..178
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 237..261
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
SQ SEQUENCE 440 AA; 46370 MW; 57DD2DB2462CDFF0 CRC64;
MHAVPAEAMN TLKLPFYRQL YFQVVAAIII GVLLGYFEPA YGEAMKPLGD AFIKLIKMII
APVIFLTIVT GIAGMTQLST VGRVFGKAMA YFLTFSTLAL VVGLVVANVF QPGAGMNINP
ADLDQKAVQG FVAKSHDMTL VGFVMDIIPK TLISPFVGDN ILQVLLVAVL FGVSLAMVGD
AGKPVLNFFE ALTKPVFKLV NIVMKAAPIG AFGAMAFTIG KFGLGSLLNL AELVLTFYIT
SAIFVLVVLG AVARACGFSV IKLIRYLKEE LLLVLGTSSS ESALPSLMEK MEKAGCKKSV
VGLVVPTGYS FNLDGTNIYM TLAALFIAQA TNTELTLGHQ IALLLVAMLS SKGAAGVTGA
GFITLAATLA VVPEVPVAGM ALILGVDRFM SECRSLTNFI GNAVATVVVS RWEKGVDMER
LHAALDGKPL PALDAVPAKA
//
