ID   A0A014QF14_9BURK        Unreviewed;      1002 AA.
AC   A0A014QF14;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:EXU81827.1};
GN   ORFNames=AX13_00820 {ECO:0000313|EMBL:EXU81827.1};
OS   Comamonas aquatica DA1877.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=1457173 {ECO:0000313|EMBL:EXU81827.1, ECO:0000313|Proteomes:UP000020766};
RN   [1] {ECO:0000313|EMBL:EXU81827.1, ECO:0000313|Proteomes:UP000020766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DA1877 {ECO:0000313|EMBL:EXU81827.1,
RC   ECO:0000313|Proteomes:UP000020766};
RA   Watson E., Macneil L.T., Ritter A.D., Yilmaz L.S., Rosebrock A.P.,
RA   Caudy A.A., Walhout A.J.;
RT   "Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans
RT   Gene Expression and Life History Traits.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXU81827.1}.
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DR   EMBL; JBOK01000001; EXU81827.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A014QF14; -.
DR   STRING; 225991.MA05_09680; -.
DR   PATRIC; fig|1457173.3.peg.162; -.
DR   Proteomes; UP000020766; Unassembled WGS sequence.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000020766}.
FT   DOMAIN          327..366
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          379..432
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          433..485
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          593..731
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          740..993
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   1002 AA;  110782 MW;  E5B696B3E008D95B CRC64;
     MGGALSLGLW HTLEAHRASM TLERLEQQAL QLSSALEQKM DAYGELVYGM AVLGKSPESL
     SSPLLPQLNA QRYPGVEFLS LVRRMPSAVA GYEMADVWPT RSTDVWMGEN AQNLEALTQL
     WARLPESLEP SMSEPFAVLG GDASPQRVVI GMPMWPASAR SAAVHQGDIL AMGLRADQLL
     EHFMARGGLE QGLVSIQDQG SASHRSATSR APRLPIYVSD GWAQLPASAP KVQHELLVWG
     RIWSLEFAPQ PQVLSALESA YPMIVGIGGL GATLVLAALV AVLSHQRLRA QFQTRVKHNL
     LRQQSDRLKA LLHQSAIGVA EIEPGTGRYL SVNSRFSDVV GYDPKTLEMM DLYQILHPEE
     RPEFQRLEGA LAAGRLAHFT VTQRMVRADG SEVWTEVWVS PVVDNTGQSM GRQIVLLLDV
     TERQILQAQL HAREAYSSEM LRYMPVGLVV VGPSGNIEFV NHQFEVMTGW SQCDMADETT
     LWRLLCVDAM QHAALLQRLN AGRCEVVPTG VNMPAAEYLL RSKDGKELPI EVSGRFLGGR
     ILLSFVDLSQ RKAAEEEIRW LGFYDTVTQL PNRRLLLERL AEAVARCQRP GGGKGALLLL
     DIDNFKSLNE TLGHQHGDAL LRLVATRLSN CIAGQYTLAR QGGDEFAVVL EDLPSEPLEA
     GRRAEQVGCA VLEALRTPFY LGAQDFHVTV SMGAVVFSGK SDTVEELLKR ADLALYQAKS
     AGRDTLQFFD PSMQKAVSAR VEMEKDMRLA LERHEFDLYF QPQVQKDKVI GAEALLRWKH
     PVKGFISPSV FVPAAEESGL ILPLGEWVLY AACRQLAQWA KDPQMAGLTM SVNVSPRQFY
     QPSFVEQVQQ ALRVTGAPPR MLELELTEGM LLADVEDTIR KMVQLKAMGV IFSLDDFGTG
     YSSLSYLKRL PLDKLKIDQS FVYEVLSSAN DATIARSIIA LGNSLGLQVI AEGVETEAQR
     EFLASSGCHY WQGFLFSQPK PIAEFETWTR AYGAARSERS HV
//