ID A0A016RTN2_9BILA Unreviewed; 454 AA.
AC A0A016RTN2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit TIM50 {ECO:0000256|RuleBase:RU365079};
GN Name=Acey_s0386.g433 {ECO:0000313|EMBL:EYB81339.1};
GN Synonyms=Acey-scpl-4 {ECO:0000313|EMBL:EYB81339.1};
GN ORFNames=Y032_0386g433 {ECO:0000313|EMBL:EYB81339.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB81339.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane.
CC {ECO:0000256|ARBA:ARBA00002959, ECO:0000256|RuleBase:RU365079}.
CC -!- SUBUNIT: Component of the TIM23 complex.
CC {ECO:0000256|RuleBase:RU365079}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU365079}.
CC -!- SIMILARITY: Belongs to the TIM50 family.
CC {ECO:0000256|ARBA:ARBA00006344, ECO:0000256|RuleBase:RU365079}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB81339.1}.
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DR EMBL; JARK01001722; EYB81339.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016RTN2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07521; HAD_FCP1-like; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR004274; FCP1_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR12210:SF3; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50; 1.
DR Pfam; PF03031; NIF; 1.
DR SMART; SM00577; CPDc; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50969; FCP1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU365079};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU365079};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365079};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946,
KW ECO:0000256|RuleBase:RU365079};
KW Translocation {ECO:0000256|ARBA:ARBA00023010,
KW ECO:0000256|RuleBase:RU365079};
KW Transmembrane {ECO:0000256|RuleBase:RU365079};
KW Transmembrane helix {ECO:0000256|RuleBase:RU365079};
KW Transport {ECO:0000256|RuleBase:RU365079}.
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365079"
FT DOMAIN 243..387
FT /note="FCP1 homology"
FT /evidence="ECO:0000259|PROSITE:PS50969"
FT REGION 70..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 52272 MW; 1D21C8CAF605E9FA CRC64;
MAFRLVLDCV QQQVSRRICS TVIRRTYCNE KVFKSLLADT RVASPFADPS KTIASPVVVD
TVKHFSVAHE APTDDRINGL KKATKERPPD PKPETKKEVP KEPKKPVVKE EPERLSAIEE
LNLLKETLSK GDDQSDSGGS KGSGDEHTFD EEAEKEKRRK RLERNTRIGG VILFGSTVAG
LVSFCLYYGR SKRDEAGNII PDEFSGSYLA PFYRIANSFK LWRDFVVEPA REQLLPDPLP
HPYIQPRYTL VIEMKNVLVH PDWTYKTGYR FAKRPALEYF LDVVGYPNFE VVIYTSESMM
TAHPVVDSFD PKQRIMYRLY RDCTKYMHGQ HVKDLSKLNR DLSKVIFIEV DPKAGQLNPE
NVLLVPEWKG NMDDTSLVDL AELLKTIHLS DVEDVRPTLQ YYSQFPDPAK EFRRRAIYLA
EQEEQRKHQL DESSHSLLKK YSGRLFGYRR HAPT
//
