ID A0A016RWG5_9BILA Unreviewed; 584 AA.
AC A0A016RWG5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
DE AltName: Full=Nicalin {ECO:0000256|ARBA:ARBA00041615};
GN Name=Acey_s0352.g3256 {ECO:0000313|EMBL:EYB82725.1};
GN Synonyms=Acey-nra-2 {ECO:0000313|EMBL:EYB82725.1};
GN ORFNames=Y032_0352g3256 {ECO:0000313|EMBL:EYB82725.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB82725.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB82725.1}.
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DR EMBL; JARK01001688; EYB82725.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016RWG5; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF0; NICALIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..444
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 584 AA; 64293 MW; 0A21A641847A4BEE CRC64;
MHSIESHHRD FRAERNDTYC RMKRWQSASS KIASRTTVII MEELLEAIRN PFFIVYISVL
LSFCVVNGSQ QLGDKVELEF QAFRLQQYEL NGNIIGSKTF RVQYEAVSLN SKALRRCVVT
SWRDLTGHTN LDDLLANSVG ALLVIIPSDL DALSPADKTL FSELERRLAT ARTDMAVYVI
YSSPEASAIL SDVQHSSGVT KSATQQLINS IAANTFQFTS TGSPSTNALT YKPNNIIGRL
SSSERSAPTI AFVAHYDSHA AFPGAAVGAD SNGSGVVVLL ELLAIFRKLY EKPATRPPFN
LVFVWTAAGK YNYQGARQFI EDFQSDNSDD HRLEMAICVE ALGGVGPLRM HASKQPADGS
AADRLLRRLR LAAPNQSVEL VTKKISMNQP SAWEHEKFNI KRLPAITLSR LPTHDDPIRK
SMLDTPSQLS LEALEQNIRT IAEAVLGHML SLPEGGYSTD PRVSADTSVL SRDAVDRQRL
AHAIRLFATR PRPVADEAAT VACAANLAVA VGNYAKVTVS PVSMHEVQIW PGVADRLMAE
RVKPAVFDLV IAGGVFAYLA AFYHLVSRAQ RVLESAMLKL RKRV
//
