ID A0A016RYW7_9BILA Unreviewed; 1438 AA.
AC A0A016RYW7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=C2 DOCK-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0338.g2936 {ECO:0000313|EMBL:EYB83302.1};
GN Synonyms=Acey-ced-5 {ECO:0000313|EMBL:EYB83302.1};
GN ORFNames=Y032_0338g2936 {ECO:0000313|EMBL:EYB83302.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB83302.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB83302.1}.
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DR EMBL; JARK01001674; EYB83302.1; -; Genomic_DNA.
DR STRING; 53326.A0A016RYW7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 418..600
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1190..1438
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
SQ SEQUENCE 1438 AA; 166018 MW; BF7B69AFE2293D40 CRC64;
MKVRFAIAFA NFTANEDLAE EARAKKAPCC FLNLIAGDRL RVYVEKEGWA IGSHIGSKTE
AGLFPLNAVN FVNRHSQTDP TAEGASIVEE INQVTQTWWR KIKEIYIKHS EMHYFSEVLE
FIDYTLSVRQ KILSGGVPAE ELNALRVQLA KKIDRGNMLL SLNVTIRDEH GLPFDPDSIS
FLQTYAEHQN AQKRVASDCI KTDTQEKSVK AFCLLLRVQC VEIQMKYNCE VSMVLYDMEA
KRFVSDTFTF IWKSSEPSSR DLNIRGLFGN FMQADIGRRL LLITRVAHIS PVEHTSSTLK
RNQEPGPPNL YCRQFFAFDF FDMTAIFSNP QQSHDAKDRV IFLNRDQSFD QAIKSMQSSG
KVPKFNTSSD DIRILISTQI FTNSLSELRL KRPYLFTRNP PAIVFRCDYA GPASVDVRNE
LYVTLLQGEL SGKSSDRNIE ARLHLVEGNG RVVPDCFETV SAGSVKLSSD YRSFVYIHDD
KPLWFENVKI CLPEDTSRDL HLRITFHTKK PYDKGKPEKG PFALAHIRLM CKSVLVPDGE
HELLVYKVES SHYDESNISY LPLPQTRRVL RDLGNTTNKP HSSVFSLSEK SFVLINTLTC
STLLTQNEHI LNVLGWREPR PNLNQSLQVL GAPFGDLQDE MVRFLCPLLD ALFELWDERE
QLELPVFDVI IALLKLTDEQ RYSYSSEMLK KYMDRFPYCN AAMKLMRCLN HYIASASISN
NEKTRNSLKV MGRVFITVVQ SKKSGDNFSD DPAYATSFRS HLDSILDSLV SLMGETRERM
TVQNTALKHL SAIVDPICAS GAYEPTDLCK FFIRVINGFG KNIVARERLG LVSQLIDTNL
FELHSCRLIL LPRCIDLILA QLDPDQNEDR EFAERAVECA TIISCLLERL FSTTNMPPQY
QCGTDEELNF IISSTYRPLV QAMVYIGQQN VSNDEIRGRF FSLILALLNK MSAQLFGNYI
ENRSSDIDKM DFILEMLQMI RDLLCKCPFP ATWHQMIMLQ NKTVHKALRF LMNAIQGYFS
NERDRFYSDL WQEYMLTAVC FVTQPSLQSN DEWLCDDAES RVQLRKAAAR DLRSMWFRLT
PVQKMAYIPR LVGAFLKVAL VEDDETREAT IPIFFDMMQC EFHSCVEDRK NFKKRVFFWS
DKELWDGGGR ELIDRVDRLL GHLFEYRLVR ETSDCMENGM SRTVQLLRYY EKYHHHDLYI
TYVYKLYDLH IVYNNQIEAA KTLMLYANTL SWDDIELDES LISRRLNRQC AFERQLKDNL
LCEAADLFAE GEMWEDAIRI LKELLPVYEK TYVDYDKLAS LMIRIAELYR KIDRENRAFF
YYYLVAFYGK GFPSYLNGIS FVFRSDKLER HADFMQRMQQ IYGGPEAIMS MDDCSHLKDS
PGRYMQVTYS KDLWRVSVVG WYGHGHVSKS TRPSALAGEA ESLKPYLSIK GTAKTLKP
//
