ID A0A016S254_9BILA Unreviewed; 432 AA.
AC A0A016S254;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=PH domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0314.g2219 {ECO:0000313|EMBL:EYB84536.1};
GN ORFNames=Y032_0314g2219 {ECO:0000313|EMBL:EYB84536.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB84536.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB84536.1}.
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DR EMBL; JARK01001650; EYB84536.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016S254; -.
DR STRING; 53326.A0A016S254; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd13250; PH_ACAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045258; ACAP1/2/3-like.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23180:SF399; BLOWN FUSE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR23180; CENTAURIN/ARF; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 161..287
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 330..432
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 293..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48181 MW; E1DF48757C5DEF38 CRC64;
MDRKQTVALL NKLNLTAHST FYSFEDLPDT PPAIKVFKRV VPPPTPKTSV YKKISDVSTS
STKSTKSVSG SFSYLAGDAP KFCDETPCVP HPVLSRTSSN SELTSDIITK TKPKLRRRPG
MKIVLPKKKT SRFYTPAAEV PVHLPATEMF QHFSGMPPDP DVMMEGYLYK RSSNAFKTWN
RRWFQIKDNK LLYSHRSADS EQPTVMEENL MLCLVRPAPS SIDRVGCFEL VTPTRHVFLL
FTSSLLIFSI PGMLPLEEHT LHESHLLQAD SEALCNDWMR ALQRTILALH ESDEVETHPT
SSTKSESKKL NTEGNRKSAN MGVPSVPDAA TTFEQIRRVP GNERCADCGS EQPKWVSINL
GVVLCIECSG VHRSLGVQTS KVRSLTMDSI DPELRDVLLS LGNSQVNAIF LAHLPDKDVV
PQPAFDNSSR QV
//
