ID A0A016S7K4_9BILA Unreviewed; 887 AA.
AC A0A016S7K4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 36 {ECO:0000256|ARBA:ARBA00039432};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Deubiquitinating enzyme 36 {ECO:0000256|ARBA:ARBA00042420};
DE AltName: Full=Protein scrawny {ECO:0000256|ARBA:ARBA00042154};
DE AltName: Full=Ubiquitin thioesterase 36 {ECO:0000256|ARBA:ARBA00041300};
DE AltName: Full=Ubiquitin-specific-processing protease 36 {ECO:0000256|ARBA:ARBA00043009};
GN Name=Acey_s0282.g1266 {ECO:0000313|EMBL:EYB86244.1};
GN ORFNames=Y032_0282g1266 {ECO:0000313|EMBL:EYB86244.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB86244.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB86244.1}.
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DR EMBL; JARK01001618; EYB86244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016S7K4; -.
DR STRING; 53326.A0A016S7K4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02257; Peptidase_C19; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF758; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 333..636
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 78..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 98770 MW; 629FAC235E23FA4D CRC64;
MMSTVDISSM LCEKILEAKI FFPKLLVTMA NNTDEAMAKC NGSDVELPFL SGDEDAICEL
IMEEDTADDE CQYPEMNASK TTGDDCGDAT GASKSRSSSL CVSPGTADSS SFLSDALDEL
DEPDHVSPML IQIYEITLNW SLQLELEISP SRKVSLSDAK PNPNDSGNSS QSDTLVDLPA
FTSPVKEDFR ASQSYDENSH ENGNDPTTSV TEGGAGTTTK LRRSSIGSPV DLEPERDDEE
VEQLAKQMSK WRSLPQLEKS KQPIVVVSRA EVPKNDEKKK ERSRSVGGPI APRVRKLSEK
GKIEQRFPVF DPDLKDIWDF KDFNVIKNIK RASGISNGGQ HCFMISVMQI LTHTASFIRF
IVEKHNHTTG GPVGRCFCCD LRKHLLRVLS TNVGSLNKMD WIFVYWKSMF GTDYYTTQED
AHEFLLKILD LIDRCSYPSS SSSDRIPKEP SPPMTQLFGF KLRYQLTCLL CGLCSVSYAL
HNDLSLHLPR GGRYNVPPRM HDLIAMYMKS EVLEYACPDK KCNGKLARRT PFIFRAPSVL
ILQVKRFFHT EKKNGMRVQV EEHLSLKDFT YSQSDGDDYE LTGIISHEGH QITSGHYTAL
VRGFDRQFYL FNDEYVRPQK LLTANLCPYL IIYSRKGPQD RVFAPAKSSD AAITNTKPLL
PQRTNSVISA KPLLPQRTNT GTSPCKDASG TGVTAALPKS PVLTKTVLPR KPKLFRDGFF
TAGSELGRMR ISKEDKWFYK PSTAGSDLEK RGSENESQKT DGDAKSGFDV VFGSEDEKGD
SNAKENEFTS SMDTQSMGFG VSKLTQAVFP EASSNENGTA DSTAQARQMN PEQLLSAINT
FVAKESRRRG SLKPSHLLKG NGCYNCVLCN SMSPNNDSSK WKKRRLN
//
