ID A0A016SC72_9BILA Unreviewed; 264 AA.
AC A0A016SC72;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Checkpoint protein {ECO:0000256|PIRNR:PIRNR011312};
GN Name=Acey_s0250.g162 {ECO:0000313|EMBL:EYB88278.1};
GN Synonyms=Acey-hus-1 {ECO:0000313|EMBL:EYB88278.1};
GN ORFNames=Y032_0250g162 {ECO:0000313|EMBL:EYB88278.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB88278.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the HUS1 family. {ECO:0000256|ARBA:ARBA00005563,
CC ECO:0000256|PIRNR:PIRNR011312}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB88278.1}.
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DR EMBL; JARK01001586; EYB88278.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SC72; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0030896; C:checkpoint clamp complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR Gene3D; 3.70.10.10; -; 1.
DR InterPro; IPR016580; Cell_cycle_HUS1.
DR InterPro; IPR007150; Hus1/Mec3.
DR PANTHER; PTHR12900:SF0; CHECKPOINT PROTEIN; 1.
DR PANTHER; PTHR12900; MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1; 1.
DR Pfam; PF04005; Hus1; 1.
DR PIRSF; PIRSF011312; Cell_cycle_HUS1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 264 AA; 30307 MW; 1EF34064930D0166 CRC64;
MTFFIIAECV GAVARLCKKR CGLRITKDGM CFVANDTLRE QGNFLSVLIP PRPDFEVYNF
AGVSEEMNEI VMELDIDDFE KSVTGVHSYL KIKLRQKPNQ KPFLQLELRD KGTVHELPVK
LIKTAHWPLY RRPDVPRGMM GVYFPPIKSV LRVLQSLRHV GNKNITLKVS NGGEMHLRCR
MDQAEVTVYF SELANDTITE EQSQEHWCTV RLSLKIVHMF FSGFMFMANL NVLLNVVSDR
FAEFILRRDG LEVSFLVGGV NDVY
//
