ID   A0A016SNE6_9BILA        Unreviewed;       610 AA.
AC   A0A016SNE6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=TIL domain-containing protein {ECO:0000259|Pfam:PF01826};
GN   Name=Acey_s0198.g1639 {ECO:0000313|EMBL:EYB92110.1};
GN   Synonyms=Acey-Y69H2.10 {ECO:0000313|EMBL:EYB92110.1};
GN   ORFNames=Y032_0198g1639 {ECO:0000313|EMBL:EYB92110.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB92110.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB92110.1}.
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DR   EMBL; JARK01001534; EYB92110.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016SNE6; -.
DR   STRING; 53326.A0A016SNE6; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd19941; TIL; 6.
DR   Gene3D; 2.10.25.10; Laminin; 6.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   PANTHER; PTHR23259:SF70; ACCESSORY GLAND PROTEIN ACP62F-RELATED; 1.
DR   PANTHER; PTHR23259; RIDDLE; 1.
DR   Pfam; PF01826; TIL; 4.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 5.
PE   4: Predicted;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          136..189
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          197..249
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          277..330
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          497..553
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
SQ   SEQUENCE   610 AA;  64735 MW;  A8A3650D6529AEB8 CRC64;
     MCMIISCTEL LTAPCTFAKK AVLFGSSLST FPWHPTLCSS SPAGAVPDKM GPATVTWLFA
     PMLTATSALS LIAGDSNGGL MHGRAHEAQS GVQSPYEANS VGMLGMTFVG APNQAAKPGM
     GPMSMNGIWS YALPTCGMNE AYTDCTSACQ PKCGVNSTTC TKECGPPGCE CLPGYFRNAE
     NICVSHDQCT TNSNTSCGKN EEYTPCSGCE SQCFGTTSRC SRECGPPKCQ CRDNYFRHMN
     GSCVAKEHCS ATTGSSKPLI LPRPGLNGTI PTVPMNCAAN EYYTNCTSSC EPRCNGTKDI
     CDKACGPPGC QCLPGYVRAD DNSCVLRKQC GGATTCGMNE EHVICSGCED KCSGERSRCG
     RGCGPPKCQC AANFYRHVNG SCVAKEHCIA SEAATSCANV LCAPKTECQM VYSSECLHAG
     HCLAVPQCIP QNLTNTCANV RCDSSRECKM VQHNCSSTPC NPMPHCLPPA SGTTTPRFGI
     NSSSTRTTPV PTDSQECEEN EEFTECMPSC QMTCTGRREC SSTFAATMCT AGCVCKAGYR
     RNADGQCVKP RRCYLSPGCK AYEEWSSCAN CENKCDGSTR SCSTCYSGCA CIRGYSRSAM
     DRCIPTEDCP
//