ID   A0A016SP09_9BILA        Unreviewed;       609 AA.
AC   A0A016SP09;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=TIL domain-containing protein {ECO:0000259|Pfam:PF01826};
GN   Name=Acey_s0198.g1639 {ECO:0000313|EMBL:EYB92111.1};
GN   Synonyms=Acey-Y69H2.10 {ECO:0000313|EMBL:EYB92111.1};
GN   ORFNames=Y032_0198g1639 {ECO:0000313|EMBL:EYB92111.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB92111.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB92111.1}.
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DR   EMBL; JARK01001534; EYB92111.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016SP09; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd19941; TIL; 6.
DR   Gene3D; 2.10.25.10; Laminin; 6.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   PANTHER; PTHR23259:SF70; ACCESSORY GLAND PROTEIN ACP62F-RELATED; 1.
DR   PANTHER; PTHR23259; RIDDLE; 1.
DR   Pfam; PF01826; TIL; 4.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 5.
PE   4: Predicted;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          135..188
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          196..248
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          276..329
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
FT   DOMAIN          496..552
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
SQ   SEQUENCE   609 AA;  64558 MW;  DEA703E89BCB832E CRC64;
     MGIISCTELL TAPCTFAKKA VLFGSSLSTF PWHPTLCSSS PAGAVPDKMG PATVTWLFAP
     MLTATSALSL IAGDSNGGLM HGRAHEAQSG VQSPYEANSV GMLGMTFVGA PNQAAKPGMG
     PMSMNGIWSY ALPTCGMNEA YTDCTSACQP KCGVNSTTCT KECGPPGCEC LPGYFRNAEN
     ICVSHDQCTT NSNTSCGKNE EYTPCSGCES QCFGTTSRCS RECGPPKCQC RDNYFRHMNG
     SCVAKEHCSA TTGSSKPLIL PRPGLNGTIP TVPMNCAANE YYTNCTSSCE PRCNGTKDIC
     DKACGPPGCQ CLPGYVRADD NSCVLRKQCG GATTCGMNEE HVICSGCEDK CSGERSRCGR
     GCGPPKCQCA ANFYRHVNGS CVAKEHCIAS EAATSCANVL CAPKTECQMV YSSECLHAGH
     CLAVPQCIPQ NLTNTCANVR CDSSRECKMV QHNCSSTPCN PMPHCLPPAS GTTTPRFGIN
     SSSTRTTPVP TDSQECEENE EFTECMPSCQ MTCTGRRECS STFAATMCTA GCVCKAGYRR
     NADGQCVKPR RCYLSPGCKA YEEWSSCANC ENKCDGSTRS CSTCYSGCAC IRGYSRSAMD
     RCIPTEDCP
//