ID A0A016SPU6_9BILA Unreviewed; 420 AA.
AC A0A016SPU6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN Name=Acey_s0195.g1494 {ECO:0000313|EMBL:EYB92349.1};
GN ORFNames=Y032_0195g1494 {ECO:0000313|EMBL:EYB92349.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB92349.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB92349.1}.
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DR EMBL; JARK01001531; EYB92349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SPU6; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF8; ASPARTIC PROTEASE 1-RELATED; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 97..413
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 115
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 302
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 337..373
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 420 AA; 46890 MW; 2DC51B52F4FA6946 CRC64;
MPCSAVQFPP RPKKQRLRSD LHQSDMWISL LLATVLSTAC AQNMTMKLVG TGSLIAKFMK
ANRYDDYLRL IDEQERSRSN GRYWTWQSLA SWYDEYYLGE VNVGTPAQKF YLSMDTGSSA
MWLIDGACTH PICNGYATSG RTKNKFYYGK STTFEKTSEK FSINYGTGWA GGFIGVDDIT
YGTYVVKQQF GVANSLGPFF GTAPMDGIFG LGFNEYENLN APMPTVKHFM DKQQFTVWMN
RRVAISKGAV GGYITYGAYD KTNCAAKIYY APLAVENKWI INIAGFGIGK YTHTADQHAI
SDTGTTWIGV PNAVLNNILW QTKSSWDASR KLYTIPCSKM YKLPNMVFHI AGVQFTVPSA
QYVLDLNLGK GQCVMAIFAV DSAAFGAQFI LGQPFIRTFC QTYDIENQRI GISIATPQKT
//
