ID A0A016SQK6_9BILA Unreviewed; 648 AA.
AC A0A016SQK6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=PDZ/DHR/GLGF domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0192.g1357 {ECO:0000313|EMBL:EYB92574.1};
GN Synonyms=Acey-lin-2 {ECO:0000313|EMBL:EYB92574.1};
GN ORFNames=Y032_0192g1357 {ECO:0000313|EMBL:EYB92574.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB92574.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB92574.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JARK01001528; EYB92574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SQK6; -.
DR STRING; 53326.A0A016SQK6; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12035; SH3_MPP1-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF7; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..648
FT /note="PDZ/DHR/GLGF domain protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001486692"
FT DOMAIN 239..320
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 326..406
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 461..633
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 648 AA; 72973 MW; 6536F4A5501758E4 CRC64;
MLHFAQILSS LDMIAALCDA PSAGSFSGTA EAVAADKGFI DLLQLYDRIS QLSCHPVLSE
QEACALHRDI VAEIGSLSTP TPEALELQQL MRLNEVESCL QAHDIVVSEV YEMEDGVEAS
QTAATTFQVG ASRMYYSSYG EDVIVPRFSS LSHRLRCCFY AKPILTKSFT LICLEIMYVD
SSTKLLISGS TSNPSCSNGG ILPLGYRGIG TCSDECLPPS FTADDDAEVM MDTISRIRLV
QFQKDTEEPM GITLKVTEDG RCFVARIMHG GMIHRQATLH VGDEIREIDG VSVANRSVES
LQQMLREARG QVTFKIVPSY RSAPPACEIF VRAQFDYDPC EDDLIPCPQA GVPFKTGDIL
QVISKDDHNW WQARFVSSFP SFGTSSLVST NVAGLIPSPE LQEWRTACLA MERAKDHSHC
MWFSRRKKYY TTKYLQKHSA LFDQLDLVTY EEVMRLSQYR RKTLVLLGAH GVGRRHIKNT
LIHRHPNRFA YPIPHTTRPP RKEEVDGKHY FFVSNDQMLV DIQNNEYLEY GTHEESMYGT
KLETIRNIHK SGKVAILDVE PQALKVLRTA EYSPFVVFIA APNLQGLQDP DGSLERLLRE
SEILRQAFGH LFDYVVINND IDETIVQLEQ IAEKLPTCPQ WLPVSWVY
//
