ID   A0A016SSY1_9BILA        Unreviewed;       597 AA.
AC   A0A016SSY1;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN   Name=Acey_s0181.g830 {ECO:0000313|EMBL:EYB93467.1};
GN   ORFNames=Y032_0181g830 {ECO:0000313|EMBL:EYB93467.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB93467.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB93467.1}.
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DR   EMBL; JARK01001517; EYB93467.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016SSY1; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807:SF110; FI17948P1; 1.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          162..363
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   597 AA;  67792 MW;  EA017B96043E532A CRC64;
     MTCLKVCLRT CEIECAFCEH CFLVWPFSEN GFGRVVCTNF RLRFELSPKA ETSLPARFKR
     FDERFDIPLC SIHSVHYAPV KQNHQSLHKK KFIHVLKSLS SLEIVSSIRL QLKDFRVITI
     DLRDSQNAAS LLNQILFFSR PLKMENVIQA GAELGWCSKL SFNDANSWEA ELRRCGHNSD
     YHWRVTSQIP HGARQFVHSY PMYFVVPADI VQYDLGRMAE HWQLSRFPVW VWSSLSGVSL
     LRSSNFDVNW EAPQLNDKFD DIFCSFRLAE CVRRATKSAE PPHKLSISDE ITPAKIAFSY
     DRLRRLCSVD SYDQFASRDK DWLARINHTG WLQLVSYCLS AAGEAVDWLT NRGRFAYSQH
     VLIALWDLSL TGMVPALASS SVADQLGLQR CGGPFPLERF FNESYTQLFA NITNMAAVAV
     QNATEAMLIE DVIRPPRSIV NVQLWNECYL RWIPPANVRR GGSLFTDLAI EDSIKRLPAS
     RIIDGKLGGI DVDFDKVSSA YPYSEADVST RGFYSKRADS DTLSISSMTL STSSNLQAVD
     DKMKHRASVP VLGGIPEGQP RSAILRHELD NTSTSNSKNF SFRLRHFNSD HNKSGKN
//