ID A0A016SWR1_9BILA Unreviewed; 608 AA.
AC A0A016SWR1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=BHLH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0163.g3479 {ECO:0000313|EMBL:EYB95143.1};
GN Synonyms=Acey-cky-1 {ECO:0000313|EMBL:EYB95143.1};
GN ORFNames=Y032_0163g3479 {ECO:0000313|EMBL:EYB95143.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB95143.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB95143.1}.
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DR EMBL; JARK01001499; EYB95143.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SWR1; -.
DR STRING; 53326.A0A016SWR1; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd19697; bHLH-PAS_NPAS4_PASD10; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF24; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 33..86
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 138..189
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 67869 MW; 5127EDFE18E609C9 CRC64;
MSTALHLPTT PSIATSPSAS RIHECPSAAS AHTPQRSTRG ASKQRRDQIN VEIQRLRDLL
PLSESIKDRL FQLQVMSLGC IYIRKHRYQK HSKNRSSVLN RCDDDKSSCA CSVLRTISEN
SIPLPKGLDA CKALRGFLIM LNRSGKLLHV SDNASEYLGH SIEEIMCQGD SIFDLVDPRD
HPTVQTELNS GPQPTTSFPE ERVFLCRLNL ARTAKRQLQY HKFVLLQGRY IHPAEYFQSL
ANTPDAAQPI FAAYCQPVIN PENAETLSSG NTDVFTSQHY LDMTFKEVDH MCAHHLGYGR
DELKGMSWYS LLHPAHIPEV AYKHRLLCQE KEGSVLALIK MRTASGAWIW LHTVFAVRGN
LSHEQQDGRR VRHVIHCYYQ TLSGIEAATL QANSWIYNMR HTYPAAFPCQ ESPTPDRPLS
PVSPFPVESS FPQTLDQLVP FIKQEPFNPM TMVPHYGISC GQIKVEIPMK TMPHISMFTP
ESSSPESSAS LTSALFSQPF FSGQGLNDSS TTMDDFNCIL PLTIKGALPD LRDGLDDFFR
EVEQPAERSA GAVAPITSTA SISHSPEQAT ELFKYLGPAL FGPTAQSNNG ESSPVTDMHC
SRKRSWVV
//
