ID   A0A016SX13_9BILA        Unreviewed;       593 AA.
AC   A0A016SX13;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Nuclear receptor domain-containing protein {ECO:0000259|PROSITE:PS51030};
GN   Name=Acey_s0162.g3438 {ECO:0000313|EMBL:EYB95273.1};
GN   ORFNames=Y032_0162g3438 {ECO:0000313|EMBL:EYB95273.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB95273.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SIMILARITY: Belongs to the peptidase M1 family.
CC       {ECO:0000256|ARBA:ARBA00010136}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB95273.1}.
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DR   EMBL; JARK01001498; EYB95273.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016SX13; -.
DR   STRING; 53326.A0A016SX13; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.25.50.20; -; 1.
DR   Gene3D; 2.60.40.1910; -; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR024571; ERAP1-like_C_dom.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR11533:SF276; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF11838; ERAP1_C; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          77..108
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   REGION          507..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  67002 MW;  5B21513BFF760D4F CRC64;
     MFNTLASLDH SDVFGDVAST ALDELIRNSA AAIGGHTGLS GIQPMAGLNS SQFTQSGNLV
     NSQETPSRGR KKNSTINLVC VVCGDQAFGK HYGVNACNGC KGFFRRRIGF RDTQLTLLLT
     VAVQAVVAAV EKSGRACTKK LWFGNLVTLN WWDDTWLNEG FTTYFEKTKL VDNADGDLEL
     HKDLFVHGND ASMRKDSLAA SRPLSSIVDI ATEIPEAFDK ISYGKGGSIL AMMRDVVGEQ
     NFRKAIINYL KKFSFKTAST EDMWKAFDET IDHVKGPTGA KLNMLDFGNQ WSKQMGFPLV
     TIESFNSSAV KLTQERYMLY PSALPLKKYR SPIYRYKWDI PLWYEKKGKL HQVWLTRDEP
     LYLEVDQAVP INVNVDRRGY FRQNYDTAGW QKIIVQFKND HEVYSGWTRH GVISDAFAAA
     LIDRLDYLTL FELLSYLPKE KENAVWNLVR SELMGLTRFF VGTDKEYADL YVLKLLEKPY
     QKSLAQYISG EVTRNGVQMF RVVGNTEEHR DGHSKQMTEA PGSSDLSDPD FASSIIESYC
     ELGSTNCSSI FQSLFEETVL NRCKGDEKSS RCVKYVHVYA PLRRCKITQI LGW
//