ID A0A016SX21_9BILA Unreviewed; 649 AA.
AC A0A016SX21;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0162.g3444 {ECO:0000313|EMBL:EYB95283.1};
GN ORFNames=Y032_0162g3444 {ECO:0000313|EMBL:EYB95283.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB95283.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB95283.1}.
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DR EMBL; JARK01001498; EYB95283.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SX21; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF273; DEGENERIN LINKED TO MECHANOSENSATION; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 521..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 74574 MW; AAFF6916231364EC CRC64;
MHGPKRIYQG KRFSTYFWIL MMLCFGILLI YQVATLIQKY VSNPTVTKIS SLTSENGMDF
PMVTMCNFKP VKKSYIQRLN TSGDFSDQLL NYLMESLMDT KALYGNVDRA HLDVGDRALR
AYQESHPNFT ILGFFDEAGF NCSETMVVCM FGLRQFDCCR FIQSKMTNMG KCHSLDLRRG
RDWMQKQIVA GVNGGLQIIL DPHMEEQLDS SGDYIEPIPT NAFDIGFRYY VHAPDTIPYL
VSEGISVSPG VSVYSAIFKK TYVLLPPENW GNCTDTWPPS FSTTLPYSLI NCNSLCNARF
FYERCGCSPF MYNIDYSFPM CTPYQSFRCI DQYARIQVNG SEYFNPQQCQ ECKVECNRLV
YHVFNSYGHG LSREALGCLN RKNIKLTKAY MRSHFLTLNV FFRDMAHTEY RQVLTTSLTE
TLGEIGGTMG MFLGMSLITV TEISLFISKI GWIAISKRRR DYLYNKKKRE QEREKQLEET
VSTFNKLRTR ENVDINDSVP ATQSRLRRFS EQILDGFRRL SKPQGRTAPL PALEKAEEDM
RSDSPEKMLE EQGKQFDDTD KNKFLHMDNT LSDPGSMIEL QIDLRDLDRK IASGFPINIQ
RRRRASAPPR APRGVKVAPM MANRSAKLNA CAPFYTATSK DHPLHEDIM
//
