ID A0A016SX44_9BILA Unreviewed; 785 AA.
AC A0A016SX44;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=HEAT repeat protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0161.g3363 {ECO:0000313|EMBL:EYB95313.1};
GN ORFNames=Y032_0161g3363 {ECO:0000313|EMBL:EYB95313.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB95313.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB95313.1}.
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DR EMBL; JARK01001497; EYB95313.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SX44; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR041389; Importin_rep_6.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF5; IMPORTIN-5 ISOFORM X1; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 638..675
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 785 AA; 88423 MW; 9EED75C8B633579A CRC64;
MSGICAFNVT KDSNYRQLAI KVLAAICEKS TAQLKKHYSV SIEFILAAVL HLMTNLTLDP
GVWLDEGDIG GENQEPTVEV AADVLGRISC ALKGKAMMKP LLFLVNKMRI CVDWRERHAA
LAGFSAILEG CEKQIEPQAE QYVREILPYL QDKHPRVRHA ACHAISSMSS YFASKLQTSC
HDTVIPALVN AVKDLSCARV SMSAISALDD FMVDGPNEIF FTHFRAIMDA YIQALAAALY
RLQTIGKTSY CEKVIFAMGL MAEAIQDRFT EFYDAIVPHL LRILMTCKAE HEKILRGKAM
ESLAMIGIAV GKEKFHDDWI VVVELFKKEM PTITFEDPLY MYYTDSCARI CKVVGKDFAS
YLPLIMNYAL QMAAYKPQIA IVDEDKAKQD DPVWTYRKIG ENFYGISSAG LDEKADTCSW
LMQYAKNLEE AFLPYVDKVA KLCVNNLQFF FMDTVRCNAA ITMPYLLGCV KGQGVAAMRQ
LWKKFYSALK NLLAREDEVE VIESIFDAFQ ESVPFLGADG LAKGEAAEIV ALFSHQLRQH
EKRRLGYDAE RGDEDHDGSK EFRKEMEMEV LARISELLHN LFEVFGEWLF EHVVPAFPNF
LQLIDPHRGY QSRQYGVCYI NDCLEFAPKK CAKYQNQFVP VMLKCLSDPM PEVRQAAAYG
FGVMGELGGP EYQSAVSSAL QPLANVTLRA DAMASEECAD ATGNAILAIS KILKFFEKHV
KLHKSLIEGS EEYKFFKALL HDHQIENMTC AMKGSRRVKI QTNCINWRKV AVAADAQAKK
KLRTD
//
