ID A0A016T1G5_9BILA Unreviewed; 867 AA.
AC A0A016T1G5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=ShKT domain-containing protein {ECO:0000259|PROSITE:PS51670};
GN Name=Acey_s0150.g2749 {ECO:0000313|EMBL:EYB96429.1};
GN ORFNames=Y032_0150g2749 {ECO:0000313|EMBL:EYB96429.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB96429.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB96429.1}.
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DR EMBL; JARK01001486; EYB96429.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016T1G5; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR003582; ShKT_dom.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SMART; SM00254; ShKT; 1.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS51670; SHKT; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU01005};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..867
FT /note="ShKT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001487079"
FT TRANSMEM 753..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 698..732
FT /note="ShKT"
FT /evidence="ECO:0000259|PROSITE:PS51670"
FT DISULFID 698..732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01005"
SQ SEQUENCE 867 AA; 95419 MW; 0E9F9CA6587163FC CRC64;
MQQHQQIIIA LALSLAVAFA DEQPAADYPT LQNTTFHQYP QNTCACAPAP VCNCVPAAQP
TCQCTATPPS NCGCAVQAQA DQCAPVCQNS CMNSCQNSQQ CPETCSNTCR TACQPITQNA
CYSQCLMSCP PKILPACDAA CQNNCITDDE YSRKLIHMMS YNTPGMLPTT TPVPPVTLPP
VTMPPMQSQC NQCQSTCGQT CQQQIPAAAP VCQQQCQQIC QPVCNPAPVT QPPPEIKVTV
QESAVKGMNC QPNCESACNQ QCVQLSQDKV EAIAPSFKRT FHADPRTIYD CRNISCVCTF
LKGSLKSNNC VLANGKLFGK ALRKEYRVLS NTERNRFHAA MWTIKRSGVF DDLARIHSRF
ATSTGAHSGP AFLLWHREFL KRVELALRLV DPSVAIPYWD SALDSHLPSP RDSVLWSDEL
LGGAKSGEVK DGAFKGWKLE NGTRVIRRNV GHRGKPMSEN NVEAAINMSS IEGILAYTAS
GKGCPVSKSW NALEYTHGNP HIFVGEDMVL TSSSANDPIF FLHHSFVDLI WETWRLRKQA
RESRELDYPQ NNSLCSSDAH FSSALMRPFD PLLNTDGLSN DYTDFFYSYS PRVTCSLANR
DCGSKYLFCD VSHGKPRCAS RAAVGGNCTG FEKGEECCYK SLCVDGKCVL IAEATTLPGD
TSVVTTKSTV KNNTNPTSKI TKSQRLTTSA VPTEGESCFN ENECCGMWAE SGHCKDNPSY
MLRWCQASCN ICTPNYNITL GRDELHVEFN DSILLIMSLL LQLAWISISA ALFGLSRVCV
KMIRSRLTWS NLVQHHVIDV ENLKPLLSGK LQTLVSMAGE VSYRLCAPWR ISTVAELLVG
LRGQHLWKNR LKASVRLDSF SDNSTEM
//