ID   A0A016T452_9BILA        Unreviewed;      1090 AA.
AC   A0A016T452;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN   Name=Acey_s0137.g2002 {ECO:0000313|EMBL:EYB97753.1};
GN   ORFNames=Y032_0137g2002 {ECO:0000313|EMBL:EYB97753.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB97753.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB97753.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JARK01001473; EYB97753.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016T452; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005819; C:spindle; IEA:UniProt.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:UniProt.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR21567; CLASP; 1.
DR   PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR   Pfam; PF12348; CLASP_N; 1.
DR   SMART; SM01349; TOG; 3.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          89..326
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   DOMAIN          509..750
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   DOMAIN          834..1067
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REGION          48..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1090 AA;  119356 MW;  C5BFC3E57C9EAD06 CRC64;
     MNSDILDSRT WVNDSFEKAL SMFRVPHAPG ENGEADQENQ VRSVPVLSRG SSMPAQKRIP
     TTLRNSGNSA GAVNEEDFRK AFTQVPKCDI YSAKELQSQL ESIRQVLENS QLDWSQRVNS
     LKLLRSILIN GGMDFESELI TGVHCLEDAL ITSVKDLRSQ VCREACITVS FLCEKLEASI
     VRLCEAILPA TIGLIQNSAK IMSSSGANAC YFIIKHVEHP KLIPIVLSYS SSKSKEIRKI
     VQDLVNQMLA IWTPTKLEKN LSGIIDCIKA GISDADPQAR TSARNGYQQL DQHFPHQAQL
     LFQSLDPAKQ RSLSGAMSAA SSSQSINSER DSLHMAHRPG GLGLNRPKTT NFFAGRSASE
     IDANAVRRAA AYTPAKSKLT GSVATRNTPA RPSVVRSGIP PSRQTPLKTN NSVNPPGSVS
     QPGSRSTSPS RTGANRRPAP VSSTPSVMSS SRIGIGRPRQ IGTREASPRR FSGGTLNRGA
     SANGHAAGND TRQLCNAIRN FSLTADDEEF SLGVLRYDQA GLTDALNACT SSNLNERKDG
     LRSLLEILKS RRNIPPPDIK KICDVLNKLL TEGNHKLLSM VMDILNVFVS SYHDSLGDWL
     QFLLLRLLHK SGVEILPTVV QPLNMALKAV RSTFRPELQL IAICKNIQDP IQTPPVKAKA
     ATLNYLHELL QGMEQGSNLS RDEVRGAVQK IFQWMEDPKN ASIKMACERV IYDFFSLNTA
     DFSTILSTYP PQWREFAYSL LKKNKPSESA VPRSPAAAPV HEAISDMSAQ ITDYVDSRGV
     MGPLATSANL SASPANVSHL LNGSSARAAS NANDTDLSLG SIGEIESTLY LKDDVHQQNK
     FIAELLNELS NLDPLRRSEQ NHALQTLQQM VSEGSLTTWE ENFKSLILHI FNVLAVNDVT
     LKRSALKLLT KICVAQAVSF YDLAEMTLFK VLDSIAEEEN PQVMNVADEC LKTLATHFPL
     HVVIRATKPI IAQENDPRVG PALKMLTRLI ESLDAEELTA RLPEIAPGVV NCYSNPQSSV
     RKSTVFCLVA MVNKLGREPV NPYLTSLSNS KVVEKKSQGV LQNFINPSTR GVHSANTDVF
     YTLLITVTSP
//