ID A0A016TD12_9BILA Unreviewed; 1383 AA.
AC A0A016TD12;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
GN Name=Acey_s0115.g526 {ECO:0000313|EMBL:EYC00547.1};
GN Synonyms=Acey-let-413 {ECO:0000313|EMBL:EYC00547.1};
GN ORFNames=Y032_0115g526 {ECO:0000313|EMBL:EYC00547.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC00547.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC00547.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JARK01001451; EYC00547.1; -; Genomic_DNA.
DR STRING; 53326.A0A016TD12; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 607..695
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 729..798
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 870..960
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 967..1048
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 502..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1383 AA; 151137 MW; A8436788989F9B08 CRC64;
MPSFFCIPLA CNRQIDSLDR RQNNLQAVPH DIDRYRGLEE LLLAMNHIKE LPKTLFRLTK
LRLLDLSDND IFCVPPEIAS LSNLVELNLS RNDISDLPEQ LKECKMLMVL DLSSNPITRL
PDTIAHCVSL THLGLNDVSL TQLPVDIGQL VNLRSLEARD NLIRTLPASI THMKNLQVID
LGQNELDQLP AEMGYLESLR ELYVDSNDLE SLPEQLTKCS YLEQLDASEN RLSSLPEEIG
DLSQLTDVNL ADNELQTIPN SIGRLKKLTI LKLEKNHIHH LTQSIGSCEQ LTELFLTHNL
LQELPSSIGN LRNLKNLNVD QNKLTAIPTT IGGCASLTVL SLRENEITEI PMDIGKCERL
TVLDLCNNRL SHLPFTINVL FKLQALWLSE NQSQAMLKLQ VERDPRTGVK VLSCYLLPQL
SAHTQNDRAG QNRSFVGGPK VHFPDQDATV DDDKLPIGQF ERHDTPHPKP QKLKKSSIDG
HVIHHDGQNQ NQPATLVLSK KPAAGLDSSP TGVPQPAPRS ALKFQSVPPT EYEPEHSVAV
PEQQIQDRVQ AKSVAFASDV PEAPSTCRLK RINTPHFKGV RGSLLTSPEK ERTSVVSPTT
REGVPRKITI TRDTNGHLGL SIAGGLGSTP FIDGDCSLFV SRVTPDGPAD VAGLRVNDKL
MKVNDVDVTC ASHDEAVRAM NEPSDVVELT VLRRDNVGAS FVRSPEQSLD VSFITDPGDL
PMHNRETLSV TLKRDASGSP GFAVASSQTG AGDGVFISYI TPNGPAGCQG KLCVGDRVVS
INGTRLKGVR HDQAVALLTG NPFEDVYITV MRDFIPRVSP LPLPSTPLIT SSPTTHSPIS
ENVITKFPSV NPLPPGQIAD TSSWDGTTEE VILMKDGKSL GLSIVGGCDH SSHPFGVDRP
GVFISKIAAN SPAARCQRLR IGDRILEVNE RDIRKAHHIE AVEALKQSGP RVVLLVTHEP
QPPGMKVIEV TRKEGQTLGI SIHGGVGKPA ANPADERDEG IFVEKVEPSS VCHRAGLQVG
HRLIEVNGDS LLGCDQSEAA TILRSSNELR ILVCDGYNKP VVPRIDDRTI TSSQSSSSNV
LVDENKLVST SSISTVANTS IQNGEHHQEA SRFDEPPLAS SSPLPTTPIV ASAPAPASKP
SRIPPAVAPK PTLRNSQLQN VPIVGDLTQP EKLTFASKVK NFEREIEVQR LATKHASASS
LPSPAMKPLI TENDALKMKE EEGQRRGTPN REAISPQESA AGFEKMLDDC VKSRIVHPKR
IDSSSPSSHL FNSEIPLNEV ERRAMEQQRR SEWRAARLRS LDQERAEADA IMDRLQLISL
PAIGEDVCVP PSERILSNDI SVERSMVVDA VTGERTVTVV EKSVTKREID VALAGGEIDY
ADK
//
