ID A0A016TDV4_9BILA Unreviewed; 1107 AA.
AC A0A016TDV4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN Name=Acey_s0110.g168 {ECO:0000313|EMBL:EYC01109.1};
GN Synonyms=Acey-npr-20 {ECO:0000313|EMBL:EYC01109.1};
GN ORFNames=Y032_0110g168 {ECO:0000313|EMBL:EYC01109.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC01109.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC01109.1}.
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DR EMBL; JARK01001446; EYC01109.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TDV4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09868; PIN_XPG_RAD2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF208; PYROKININ 2 RECEPTOR 1-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00867; XPG_I; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022759};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022759};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..388
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 457..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1082
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 125407 MW; B2EF7843EF548353 CRC64;
MISSNLARVQ VNAINATDAS KIMLNVTNIT EVVEEDWTDL CEDGSLLDQD SVRFPLILIY
LFVFTVCLLG NFFTIVVIVL HPTMRTGTNY FLANLALADL LVAAFCILQN MVHIVGFDHG
NWTLGEAMCY IYVFMLHFIP CLSVGILVCV SIEKYLVFMH PFSKWTQQIL RRRVRFMMTM
ATWALSIASN IPYALNTRLY RFSDTAAACG RTDTLRVWVT VSFILWYIFP LTVLALMYTN
IGMMLWRSGS CVITVTRPSS DSQSSGQTGA SWQMSNGRTI VYKQDSLLQV PEDPQVKKRQ
RDLTESRRKV PYMPPALRYY DSATPAWVVR LLIVLVASFA ILTLPHHARL LHTMWSTTPQ
CNNDWSILLQ PLSYIFLFLS SAINPILYAF LSKRFREAAS DIFYCKKGID YRSRPHISAY
LNVPLEIAPK DERSPSRKGL FSHLSRTRSR TRTIVSDLPE DSRALNPSAG SQTQSEIEAV
KNKLTSTTSK RQRFENDLFD ILPANPVEVV DLSDDDEDIV VLEEKRADRD SPPSRTIDLL
MDERERIRAS RLKPSQIPSD SKTFSDFQLQ RLLLRSRLNN HIQQLCENRE PEIPKEYLPD
AYSQHPLFAI ADNDEEESST GESEEEQFYS KTTMIEDLAK RNAGHRAADP VILRTDDWSS
DSGTDDFIDV PSTDSVIEQY LLEEKPGTKE EVQEEKADTK EEPLEEKPST SKTSDVVESS
ANEESQDSKF SSSKDTDDQW EPALDDEIQW VDRQDNGDSV AARNRDSELY KDLQEFLSAC
GFPWIEAPGE AEAQCVELER LGLVQGVVSD DSDVWAFGVK NVYRHLFSKT KNVQHYGSRI
IQQSLGLSQS EFVGIAILSG GDYSSGLAGV GVVNAIELLS EFAVTRSADE GRSLEAETLS
TLKKMEEWLK TFESDVETPE PIAIRRKLRT LIKKNNEMDR IKLVANPDVV AAYFRPNVDK
SKEKFRWKSV DVEKVRALLY TRLGWDDAKF ERQTLIALQR WNDFITGKTS YQRHITSYTH
KLQQSPDEQK TTLTKRVETA LAKLAKKTGS SSNPAAIATQ PPKPPARKLP QRKGRPAKKR
AKSSRSSASP QDLQLSEESD SDELSVV
//
