ID A0A016TIA0_9BILA Unreviewed; 2338 AA.
AC A0A016TIA0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=EGF-like domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0100.g3278 {ECO:0000313|EMBL:EYC02405.1};
GN ORFNames=Y032_0100g3278 {ECO:0000313|EMBL:EYC02405.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC02405.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC02405.1}.
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DR EMBL; JARK01001436; EYC02405.1; -; Genomic_DNA.
DR STRING; 53326.A0A016TIA0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 14.
DR CDD; cd00110; LamG; 3.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 17.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 21.
DR PROSITE; PS01186; EGF_2; 15.
DR PROSITE; PS50026; EGF_3; 22.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2278..2301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..73
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 75..111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 151..187
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 188..226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 233..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 273..313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 360..394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 396..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 439..605
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 607..643
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 649..818
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1285..1539
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1567..1603
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1629..1793
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1795..1831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1833..1868
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1870..1906
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1909..1946
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1948..1983
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1985..2021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2023..2059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2060..2096
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2098..2134
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2136..2173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2175..2211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2224..2264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT COILED 1134..1169
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 63..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 101..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 177..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 216..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 259..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 303..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 384..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 633..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1593..1602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1821..1830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1837..1847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1858..1867
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1896..1905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1936..1945
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1952..1962
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1973..1982
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2011..2020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2049..2058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2064..2074
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2086..2095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2124..2133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2201..2210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2254..2263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2338 AA; 256767 MW; BC46FAB81CB00408 CRC64;
MKDDHCSSIT KLPTIAVIDS FVCSCPPGFA GRICDADVNE CELTPCQNGG TCINLDGSFE
CLCEMRFTGQ RCEEERATCD GNPCLNQGTC IDTQDGFQCM CPHDFEGKTC QNEKSTSTCR
CPSPWHICTL VDGKPTCGCP QGLSGDKCTN IIEGCDSKPC RNGGRCQDVP GGFHCYCPPD
FGGDTCENKG QCLVDGSPCL NEGRCIRGLS ENYCECSNNA TGRHCELGFS TVTTGHCDSN
PCLNGGTCHD DGNSATCECV KGYSGQMCAE LGSSTTCNPN PCRNGGECEI VEESSQDGFS
CMCAPGFEGI LCENAGTEWT SNVEEVNTAS PSLSIFVNDT TTANVTPVIM TTKTESSGGE
VSSCNSCVHS HKCVESALGA LCICQSGYQG PRCDQHGEPC EFVRCPRSLT CRPLIAVGEV
HTSCSCPIGL TGPKCHRSTV SSFNENSLFI HQSPSVMIGS SAGPLPYKLS FSMKTTVPNV
HIASGENIFG QRLFSISLAD GHLIISIQGT THKKIIPFSL NDGSWYTLTL EKNVQDVIIS
AVNEDGYQLV LQSFPRQTTF DVFTTRFGKI NDSEFYVGCV ADFSIVDSEI DLASSSRGTS
IARGCKHSGL CSRNSCLNGG LCVDLWTHSS CSCKPPFLPP LCMHSLPPST FGHNNQTSFA
EIQIPFEISQ DLRFSAKIQL ILRSSRPNAA VLFLGEATDE LATFTSVSLR DGHVLVRSQA
GRKSVLELTS RKAVNDNKDH LIQVHRQRRH VRLDIDGQLD SEGTIPSRFD HPMFVEKLQL
GSTQRVSRDA FATDIEFKEK KRKTSISNDY IVERNDRCDR ETRWKGSKSR EIGDGIKLFY
HGLEAKRNSV AIAVSGPLKE HVSSVNRVSD NIISLRIATK DGFWTVVSVY APQCGCTEAD
KEAFYEELDD VIRSAPEGDF MTVAGDFSGH VGQDRQGFER VHGGIGFGRR NQEGERIIEL
AEAHDLAIAS TFFIKRESQK ITYCSGGRQS EIDHILVRRQ FLKTVKDVKT IPGEEIAGQH
RPVVADVCIA LPKQTKAVRE PRIRWWKLTR ETQKTFREKI AAVGLPDPCG LINPVWASAA
STILTCARDT LGETKGGMRG DRATWFWNED VQKMLKTKKD AYKAWQKTKS LSMLAEYKLK
KKEAKAAVAR AKNAAMDELY DKLESSQAEK HVFRLAKARR RASLDVTEVR AVKNEDGEVL
RDAVAVKERW RAYFEQLLNE EFSRKERNSA EPVAGPIQPW TVDEVRMAMK KMKAGKASGP
DGIPVEAWRS LGELGVRWLT MFFNNITRSE KIPEAWKDSI IVPIFKRKGD AMNCANYRGI
KLIAHTMKIY ERLLDMRLRD MVEIASDQFG FVPERSTIDA IFIARQVMEK YREKNKPCHL
AFLDLEKAYD RLPRAVLWEV MRERGIPECM VRTVQVMYDG STARVRTSHG ITSKFDITVG
VHQGSALSPF LFIMTLDTVV KHLLEGPPFT LLYADDVALI ADSRAELQLK IQKWQSALAD
AGLKLNLRKT EIMSSLGGDD VVLDANGSLQ DIRINGKSVV LHQQPTFTVD LLGKVTQLKN
VLEGSISDDI CRAQELCIHG KCHNTFNDFE CICEDGFSGR TCDQKDYCAN SPCPVNAECE
NIGDGYVCTS PVTLRKTSVM SFKMSRPEKT TSFIKFSVRT HSQDGHVLTV VSKEASFKLS
LANAQLVVTS AAPTSIRKTI SDGQWHVVQL NKNVVYIDAA GYGLPPSAQL PSHIWSGSLR
FGSAGSPSFE GCLKDVTVGD LPPLSFYKEN ESGQRSNMTY WANQERQKVT TTCLSSPQCG
IASPCIRGEC RDLWNTFTCI CPLGFGGTFC EINLDDCART DCGNGYCVDR IGEARCYCDA
GFTGETCDYE MDMCATMPCK NGALCSSSNG TFECECRVGW VGKTCEIQDG SKCGEKTCRN
GGTCENEEGA SVVCLCPPGF AGTFCEERKD PCENRPCAHG YCRANAAEFE CECEEGYGGK
TCSDIIDKCN DTLCNGQGQC APVWNATVCR CDKHWRGASC NQLVDECMNI PCDNDGTCES
TENGFKCHCR KYFLGDHCEV LGSCLANPCE RGECIQLSPD RHSCSCPTGY EGTRCESRID
YCKENLCSNG GTCESLLGEH KCHCVAGFTG NSCETDIDEC QFGYCLNGAR CTDRVADYEC
NCEGTGFTGR NCTVDINECE VSSSCLNGIC TNTHGGYRCD CELGYIGRRC SIRDPCQPDA
SNKTTHSCVH GKCVNPAVKE DHLGHETPIH GCKCNRGYTG AQCSTLVPAH KVLSLSSIVG
PVVAVLTVLI ILGCTLLAFF LRGKRSIHGH YSPSHQERTG ARLQMSSMIK LPPEERLI
//
