ID A0A016TM37_9BILA Unreviewed; 413 AA.
AC A0A016TM37;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Zinc transporter ZIP3 {ECO:0000256|ARBA:ARBA00039395};
DE AltName: Full=Solute carrier family 39 member 3 {ECO:0000256|ARBA:ARBA00042778};
DE AltName: Full=Zrt- and Irt-like protein 3 {ECO:0000256|ARBA:ARBA00041702};
GN Name=Acey_s0092.g2590 {ECO:0000313|EMBL:EYC03727.1};
GN Synonyms=Acey-F55F8.9 {ECO:0000313|EMBL:EYC03727.1};
GN ORFNames=Y032_0092g2590 {ECO:0000313|EMBL:EYC03727.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC03727.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00036307};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352;
CC Evidence={ECO:0000256|ARBA:ARBA00036307};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC03727.1}.
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DR EMBL; JARK01001428; EYC03727.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TM37; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProt.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR11040:SF214; ZINC TRANSPORTER ZIP3; 1.
DR PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR Pfam; PF02535; Zip; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 413 AA; 45285 MW; AAF640CA857A0638 CRC64;
MKCITIGASM LSLYNFYIDY PVAELLSCAG FFLLFFLEEV VIMAIPSLAH SHSHGGHGHG
FSLGESSPLT KQEVGGCCMT GNYVPPPTST EANEHCVEAT SELIKENERE NSTDGEEGAG
HCQKHCPLTV HRVRRSSEPK EPQCRTNERT ALFQQRLRSY DSIGNSGEVR ESRRASRKSS
CPCEAHTGVF TSLVFAEPER CEKNCEKVNE DPPILMKSSP HAHSHGVRSI TFVLALSIHS
VIEGIALGVG DNASETTALF LSLLVHKLIV AFSVGLQLAR THAHQLQWVV ASVFTFALMS
PLGAIIGMAV QSAAANSFSK DLTVTVLQGL AVGTFLYVTF FEVLLHERDN EHPNLLKLLV
MLIGFSMIGL LRLIDNHDHS DLSHSLVNST QIGAMRGAHF GHHHHHDHHD HSH
//
