ID   A0A016TPD1_9BILA        Unreviewed;       655 AA.
AC   A0A016TPD1;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0087.g2042 {ECO:0000313|EMBL:EYC04492.1};
GN   ORFNames=Y032_0087g2042 {ECO:0000313|EMBL:EYC04492.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC04492.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC04492.1}.
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DR   EMBL; JARK01001423; EYC04492.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016TPD1; -.
DR   STRING; 53326.A0A016TPD1; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          291..558
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   655 AA;  74997 MW;  589D9B0F4D599B76 CRC64;
     MKKDHRRWTW ESPNGTTHTE IDHILTNRRW CLLDVSVVPS FCCGSDHRLL RAKIRFSCTI
     EKNVCHRGGG KRAVVYDGAV LEKALSELDW HIMEDPTEDY DLLLQKLQAC AEHASTPQTT
     NLERISLATK ELLERRRALR LDPNASHIEQ LVANACCRRA LQEDLQKHRR KKILEAAEGR
     RSLKKCRRDL RDHNIPLTAL LNEEGIVTSS RREMEAITER FYTNLFRSSV PVMNPNIPAG
     DEPPRILPAE VRVAIQSMKP STAPGPDRIS ADLLRAGGHH LHVILAEHMS SYLRKERIPN
     QWRTSRTVLI HKKGDREDLR NYRPICLLSV LYKLFTKIIL TRISRTLDEA QPQEQAGFRQ
     GFSCMDNIQT VSRVIEVCRE YRLPLVLTFV DYEKAFDSVE TNAILSALVD QGVDASYVRT
     LADCYRQCST TVQLFQRPIT IPIAKGVRQG DTISPKLFTA ALQWAMKSLN WDERGIRVDG
     RFLSNLRFAD DIVLFSRSTE EAQAMLNELN EVGKKIGLRM NRTKTKFMKN AFCDGERIEL
     EGTQIAETMS YVYLGRSLNM ENDLKEELGR RRRAAWAAFG PLREATDQLT DHELRAHLFD
     STVLPALCYA AETWSDTAAT LKSLRTVHRA LERCLLRYNR RTQLQAGLFV PAVPI
//