ID   A0A016TPK0_9BILA        Unreviewed;       929 AA.
AC   A0A016TPK0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0086.g1941 {ECO:0000313|EMBL:EYC04705.1};
GN   ORFNames=Y032_0086g1941 {ECO:0000313|EMBL:EYC04705.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC04705.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC04705.1}.
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DR   EMBL; JARK01001422; EYC04705.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016TPK0; -.
DR   STRING; 53326.A0A016TPK0; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09076; L1-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          557..825
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          482..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  104420 MW;  75B0C6B8F9AB9E12 CRC64;
     MENGSMLLNQ ATASGATDAP VLGTMGTGVK WTTGRKENAL RRIKGKPGIT PKKELRIAAW
     NVRTGHQVGQ KEIIARELTR CKISIAALSE LRMNGSGAAT IKVPDSDQTM TLYYSGGDEH
     REGVRFMLSG RVVATVAAFQ PVSSRTAVIS VCGTVTVHIL CIYAPTEMSP DSVKDEFYGQ
     LQRVVDAIPQ SELVIIAGDF NAHVGADRQG WEGTLGRFSV GEVNDNGLRL LSFATTNKLV
     IGNSYFQRPR KYQMTCPMGH DSTVLDYVLI SSRFMSSLKD VRAIRGPDCG SDHYLLRAVM
     QLRLKRTTSK SHPVPKLDWS SLMTPPSQQL FQIALSNRFA ALAMGTNADE EEKQMSDVVL
     ECAKSLCPVI RRRTQPWITN ECLQLVDERK QAKLVDSDRY RQLNQKLRRR MKMEREAYWN
     RVADELEEAA GRNDYHMLYR TIRGLSGKTR ATDDNVRKAD GTFARSAAER LERWKEFISS
     GRNSYNHESP QGPPPEPLSI QTPRNAFLDG EPNIDEIRKA VRSLKNGKSP GVDNITAEAI
     KAGGEVLLRR LHSLISLVWQ TEVIPATWKR ALVVPIHKKG DSRECKNYRG ISLLSIVGKV
     FMKIIQTRLQ EHREQTSREE QAGFRPGRGC CDQIFVARQL MEERIRCGKR TVIAFIDFKF
     AFDCVHWPAL WKSLEAEHVP WEIVRLLQAT YNGSSSSVRI KNELSEEFPI KTGVHQGDVI
     SPQLFNIVVD AIMKKVFDGR SGVQYGDNQF LTDLMFADDS AIFAETDTEA TDIISSIAEV
     AESYGLRING DKTKIMTTDG SEAKVYLEGV QLEQVQEFKY LGYLLEEKKV AATAEVNSRI
     GKASAAFASL KRCVWKKNGI SLTTKMRLFR ILVMPILLYG SETWTLLKLD LNKLDTFQMR
     CLRQILRITI LSRIRNEHIR DSCGHQPTV
//