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Database: UniProt
Entry: A0A016TZC4_9BILA
LinkDB: A0A016TZC4_9BILA
Original site: A0A016TZC4_9BILA 
ID   A0A016TZC4_9BILA        Unreviewed;       488 AA.
AC   A0A016TZC4;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=Acey_s0067.g130 {ECO:0000313|EMBL:EYC08126.1};
GN   Synonyms=Acey-inx-10 {ECO:0000313|EMBL:EYC08126.1}, inx
GN   {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=Y032_0067g130 {ECO:0000313|EMBL:EYC08126.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC08126.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC       ECO:0000256|RuleBase:RU010713}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC08126.1}.
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DR   EMBL; JARK01001403; EYC08126.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016TZC4; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF14; INNEXIN-10; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        182..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        280..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   REGION          381..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  56846 MW;  A66CAD804376474D CRC64;
     MLRYVAGSED RDFVDRLHSY FTCNILIGLA VLVSFKQFGG KPIECLVPDM FSSSWEQYAE
     NYCWAQDTYY VPMGETVAGL ADSERRQRRI SYYQWVPFFL LLEAACFRLP SLLWQYLAGH
     SGIKIHEVVK LSSDPNNIKP EIKRANIKSL TIHLQGALRF HRRLQKKQIR PHRVLWMFNL
     PYSAFFVTSM YLCTKFFYLA NVCLQLLLMN KFLETDKYAW YGFGAMIDLL NGTTWQQSGV
     FPRVSLCDFD VRVMGNVQEH TVQCVLVINI FNEKIFIFLW FWYLMLMVFT LGSFLYWLFV
     AIVPYPNRRF IKRHLEISEM PFDPIESDKD VRRFIDCYLK SDGVFVIRML TLQSGVIFGT
     DLVLALWKSF FGIEEQLKRS NSMPDVQKEP TEDEPHFWPP PPDSFRDNER IRMRKALGQN
     IDNSEITQDL LQKLIAPYPD RPAPRYVAAV SVPLVENEAN EARIRSMEGT PVKAKTVAAV
     PASNLVNR
//
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