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Database: UniProt
Entry: A0A016U072_9BILA
LinkDB: A0A016U072_9BILA
Original site: A0A016U072_9BILA 
ID   A0A016U072_9BILA        Unreviewed;       449 AA.
AC   A0A016U072;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Cation transporter family protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0066.g3750 {ECO:0000313|EMBL:EYC08411.1};
GN   Synonyms=Acey-ggr-1 {ECO:0000313|EMBL:EYC08411.1};
GN   ORFNames=Y032_0066g3750 {ECO:0000313|EMBL:EYC08411.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC08411.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC08411.1}.
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DR   EMBL; JARK01001402; EYC08411.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016U072; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18987; LGIC_ECD_anion; 1.
DR   CDD; cd19049; LGIC_TM_anion; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF538; GLYCINE RECEPTOR SUBUNIT BETA-TYPE 4; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           19..449
FT                   /note="Cation transporter family protein"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022264688"
FT   TRANSMEM        241..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        266..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        299..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        423..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          34..232
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          241..437
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
SQ   SEQUENCE   449 AA;  52455 MW;  6EC129AB1F77401D CRC64;
     MPSMTLIVLF AVLSTALAKT DPDAIDDVRK IIANGPYYNR NAYPNQELDK PTIVYIQMYI
     EGMSSFRAQS MDFQVDIYFQ EKWIDPRLMH NNTKRILLKD PHLFKLIWHP DIYFANARTA
     EFHDVTQPNF LVWIYPNGTV WYDCRISLTV LCMQNLARYP LDSQSCALRI LSYAYDSDEI
     IIKWNGESPV DVNPEIRMPD MRLRTISHTI RNDTYATGIW SCALAEFHVD REIMHHIIQS
     YLPTALIVVI SWFSFWLDVE AVPGRVSLSI TTLLTLATQS SAARMALPQA SYVKAIDVWM
     GACMTFVFSA MIEFTVVNYC TRRKPRKHEK STKGLSEQVH SLVAQYKEKK AYQNGTCYEV
     SLCENENSQQ NLEKKQLREM NQPSILMRQN FLSSTKRKAI EERMNRVEEN RKYAQLIDRR
     SRVYFPLAFI IFNISYWVYY IKYAVDTIE
//
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