ID A0A016U233_9BILA Unreviewed; 550 AA.
AC A0A016U233;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Kunitz/Bovine pancreatic trypsin inhibitor domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0060.g3075 {ECO:0000313|EMBL:EYC09369.1};
GN ORFNames=Y032_0060g3075 {ECO:0000313|EMBL:EYC09369.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC09369.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC09369.1}.
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DR EMBL; JARK01001396; EYC09369.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00109; Kunitz-type; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR PANTHER; PTHR10083:SF352; TISSUE FACTOR PATHWAY INHIBITOR 2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00014; Kunitz_BPTI; 5.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00131; KU; 5.
DR SUPFAM; SSF57362; BPTI-like; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 5.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..550
FT /note="Kunitz/Bovine pancreatic trypsin inhibitor domain
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001491852"
FT DOMAIN 31..81
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 95..148
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 194..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 274..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..376
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 388..444
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 455..511
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 550 AA; 63732 MW; 6E8C1B92647219DC CRC64;
MRLIVVVISL LSAKHGFSGE PVFVRNPEDR CKETVDPGPC QYYQVKWFWD EVDESCKEFH
YGGCMGNKNR FNTKHECLKQ CRYKLFNPVA VPDLCLLEPD PGHCTDETKG QWWFFFNSDA
GICEKFFFYG CGGNDNKFYS LHMCNKVCGE RLSPQIACEH CDLRTSFCKS HSKVNYTCEC
RLGYEKNQYG ECIDIDECRG YTAACDRNAW CTNTIGSYSC ECMASYRGDG KHCTYVGLGR
SSLDCKDCSS DATCENGICQ CKEGFEGDGF NCTDVNECLR APYICDKNAE CINRDGSFIC
TCLSGYAGNG YNCTKTKNAC LDKFDRGYQE TCGGENWRQH FFLNHESKTC QPFWYDGCKG
RSRNIFSDQE TCEQMCEATN ILTRAEVCWD KFDMNYRNQC LNGQWQQRFY FDHASLTCRQ
FWYDGCRSDS RNMFEDMLTC QWLCETQPMY KSRACLQDFD QHYKDQCNGG RWRQQYYFDR
YVKRCIAFWY DGCTGESENL FQDEQTCLLT CENPAKKDSL KPWHGGDKHK MKEKLESIYS
XSDSGLGGRR
//
