ID   A0A016UDI7_9BILA        Unreviewed;      1060 AA.
AC   A0A016UDI7;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN   Name=Acey_s0044.g1042 {ECO:0000313|EMBL:EYC13220.1};
GN   Synonyms=Acey-T27F2.2 {ECO:0000313|EMBL:EYC13220.1};
GN   ORFNames=Y032_0044g1042 {ECO:0000313|EMBL:EYC13220.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC13220.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC13220.1}.
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DR   EMBL; JARK01001380; EYC13220.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UDI7; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF70; RAP-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          488..705
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          133..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1060 AA;  117877 MW;  FBD1DB4389D18AF8 CRC64;
     MGGDGGDLLT ASERTRRDRS AYDGIFAAVS NLDFLDVFVE KFCKLASVYT CQRDLQSAPA
     AIELRSAQNP RRCSPPIPLD RLNARLEPVC DAVFRDMMEP AGDACCGATA RALDMFNRRG
     SVIAVVIGGK SRNAPAPARA TARRTSTDAA EQQQFELSHH PGNPPDLMSS CTGSSSSVIP
     SDHPSNNSDI DTHCQVDPQS DWRPPYPRLI AFHDCLSLAS AWSLGLNPSL IDDRPTGASQ
     AQSPCEDDSG DGKSNEMLAS CPAFRNELGS EPTRRLALSR HTNDGPLEVH ECESWMREHT
     AAEAGILEDV SNVYLGGRLC AARQPKNVIE PQDIGSYYYR HCFAGRAHVE YFGVDDELGP
     IAVSMVREAT EKKGDRQSAA IYRLIIRIRG KKHGKKIVCP SFGYASHMSE RKRTNVSQAF
     KQLEPHLILA PGSKLRTMRV AVPEEALSDS ADRSTRPLMR ELMEMVCPRV SFGCMRPALQ
     SPRVEELLMK MDEQPIYTRY KVGIMFCRAG QSTEEHMYNN EHSSAAFDEF LDFIGQRVRL
     KGWDQYKGGL DTRGDTTGTH SIYCEYQAHE VMFHVSTLLP FTPSNRQQLS RKRHIGNDMV
     TVVFQEPGAL PFSPIAVRSH FQHVFIIVRV HNACTDNVSY SVAVSRSKEV PPFGPPLPKG
     ATFSKCADFH DWLLTKIINA ENAVHRSKKF ATMAARTRRE ALRDLAENYV GTHQNEGPSR
     IASRFLGGSV KRRERQNPKP FLANTRGALS WLVDVHDHST NQRVSCVLGL SQDALVLLER
     PSGVPIFCTP THSIIGWANT DMGLKIYYDH GDMLLLRCCT ETGTDVELNL LLQRLQAVTR
     GDEAKEVVLR RARLSDSWGF HVQDEGVVTD VEMYQTAWKA SLRQGSRIVE IESLTVATLS
     FDKISEMLSE RDAVRLLLIS PANDGSPRRG CEDPHCPAVK GVEQMLTPDA FARQPISYQE
     MFRMRNREYG TSPANSPAGS LEDRSFNFTV KRTDGMRANS TCAASGCPPS AALTSMNRQT
     SSVHDHMCLM LNAPKTLCRA QSDEHLRSPI TEENRKVKKW
//