ID   A0A016UEE9_9BILA        Unreviewed;       986 AA.
AC   A0A016UEE9;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0044.g903 {ECO:0000313|EMBL:EYC13301.1};
GN   ORFNames=Y032_0044g903 {ECO:0000313|EMBL:EYC13301.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC13301.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC13301.1}.
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DR   EMBL; JARK01001380; EYC13301.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UEE9; -.
DR   STRING; 53326.A0A016UEE9; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09076; L1-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR46238; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46238:SF8; RIBONUCLEASE H; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          542..800
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..986
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        930..986
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  112282 MW;  D54D5BBACBEEAFE2 CRC64;
     MRGSIWNTVN ARTSPGSDLQ EARPPPVVKK RGLPREERPR LKTLVRVGSL NVGTLTGKTR
     EIADFMARRR IHVLCLQETR WKGSKAREIG DGVKLFYYGI EAKRNGVAIA VSEPLKEYVS
     SVNRVSDRII SLRVATEDGF WTVMSVYAPQ CGCTEAEKEA FYDELDDVIR SAPEGDYITV
     AGDFNGHVGQ DRKGFERVHG GRGFGRRNQE GERIVELAEA HDLAIASTFF MKRESQKITY
     CSGGRQSEID YILVRRRFLK TVKNVKTIPG EEIAGQHRPV VADVCIALQK HTKAKREPRI
     RWWKLAGETQ KTFRDKIIAA GLPEPYGHID SVWASAATTI LTCARDTLGE TKGGRRGDRA
     TWFWSEDVQK IVKAKKDAYK AWQKTKSLSS LAEYKLRKKE AKAAVARAKN AVMDELYDKL
     ESSQAEKHVF RLAKARHRAS LDVTEVRAVK NEDGEVLRDP VAVKERWRVY FEHLLNEEFP
     RKPKAPAEPV AGPMQPWTAD EVRKAIKKMK AGKATGPDGI PVEAWRSLGE LGVRWLTEFF
     NNITRSAKMP EAWRDSIIVP IFKRKGDAMN CTNYRGIKLI AHTMKIYERL LDMRLREMVE
     ISPDQFGFVP ERSTIDAIFI ARQLMEKYRE KNKPCHLAFL DLEKAYDRLP RTVLWEVMRE
     RGIPECMVRT VQVMYDGSTA RVRTSHGMTS KFDITVGVHQ GSALSPFLFI MTLDTVVKHL
     LEGPPSTLLY ADDVALIADS RAELQLKIQK WQTALADAGF KLNLKKTEVM SSIGGGDAML
     DENGTAFTQT EEFQYLGSVL SADGTVDAAV RGRIACAWLK WRESTGILCD RRCSRVLKGK
     IYRTVVRPAM MYGSECWPVT KAHERMLNTA EMRMLRWACG LTRRDKVRNE DIRALMQTAL
     IQQKLRAQRL RWFGHVMRRS PLHPTRQAME MEVSGKRPRG APKKRWKDTV SKDMRELGVT
     KDDAQDRDLW RRRTKTADPA NARDKR
//