ID A0A016UGQ0_9BILA Unreviewed; 851 AA.
AC A0A016UGQ0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN Name=Acey_s0042.g690 {ECO:0000313|EMBL:EYC14061.1};
GN Synonyms=Acey-F53A10.2 {ECO:0000313|EMBL:EYC14061.1};
GN ORFNames=Y032_0042g690 {ECO:0000313|EMBL:EYC14061.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC14061.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC14061.1}.
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DR EMBL; JARK01001378; EYC14061.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UGQ0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF32; RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 362..578
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94858 MW; EA826AAC8A49C439 CRC64;
MCSAEQSTPL PRRMRFIDSS EDEAEGDGRG GLIGMEKQYP TAKFGARRRA RMAPSLAPIR
EPFRESVSDY TPPNRAVSMD CVVQAVAAAQ VPATLSKRLS STSLMMSSEN EFKVMAAGKL
IEAMENLKKA EMVPFKGSTE SLPASSPRRP TNGKSPFDLL GYILGKKTSE KSLNNLVSPP
ILISSTCTAV SLQELPSTNG ERKRDNMQTR DIMKEMLQRP GPYPQIVLPS TGFWMDGVSQ
NNMYLDQEIM GVNTNSCARF KLETDETSHC YRRYFYGREH HDFIAMDPAV GPLVLSVRTE
VISSQDHFRI MLRTKKGTTH KIISASALAD RPSASRMARL LSEEITTEQF TPVAFPGGSE
LIVQYDEHVL TNTYKFGVIY QRSGQISEEE LFGNARGGPA FQEFLSVLGD TVELQGFSGY
RGGLDTVHGQ TGLQAVYTEF RGREAMFHVS TMLPYTLGDQ QQLQRKRHIG NDIVAIIFQE
QNTPFAPDMI ASNFLHAYIV VQPIDALTDK VRYRVSVAAR DDVPFFGPTL PAPSIFKKGQ
DFRNFLLTKL INAENAAYKS AKFAKLAERT RSSLLDSLFM NLKSRAEFYG SPLLETTESS
GGLFSSVKKA LIGRSRSVSQ DVAQPARAVS MSTPTRAFSV PKRTANSERD KSSSSSGTSS
LRRDSPVRDD QSDSQADDDT LSAAVSPNRG VQRRIVNRHL NAKPSYQSQP KMEWELSSVD
NDSPENEIDS DTGMGGISYC TTFDHLFLHQ EPMQCILQLR FAFRLSGKVS LSSSYPRNTF
LKKVGCCDNF LWKIHKTFEK DFADQTSLKR KKCSCQIWPD FPRKRSLGNM RAKNHGYSML
LVMANSTKIA F
//
