ID A0A016UIG0_9BILA Unreviewed; 305 AA.
AC A0A016UIG0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=TIL domain-containing protein {ECO:0000259|Pfam:PF01826};
GN Name=Acey_s0040.g337 {ECO:0000313|EMBL:EYC14671.1};
GN ORFNames=Y032_0040g337 {ECO:0000313|EMBL:EYC14671.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC14671.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC14671.1}.
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DR EMBL; JARK01001376; EYC14671.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UIG0; -.
DR STRING; 53326.A0A016UIG0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR PANTHER; PTHR23259:SF70; ACCESSORY GLAND PROTEIN ACP62F-RELATED; 1.
DR PANTHER; PTHR23259; RIDDLE; 1.
DR Pfam; PF01826; TIL; 2.
DR SUPFAM; SSF57567; Serine protease inhibitors; 2.
PE 4: Predicted;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..305
FT /note="TIL domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001492398"
FT DOMAIN 103..157
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
FT DOMAIN 242..290
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
SQ SEQUENCE 305 AA; 33146 MW; E07D8AE04D8DA122 CRC64;
MHLYSGILLV AFISTSMSAN ESSVAAAPPS CSCVTCNKGE VCEMAYRIGC VSGQSPCEQY
PACVPAKQSC AATKCEENQK CFLREVFCIT TPCYPQPFCE TQCPENEEWR ECPSNCEPSC
ANQSPICNLA CLLKPQCQCK FGFYRGPGGK CVPVEQCKGA DPTCENTSCD ECKKYSKDCI
CEMVKPQGCV DGKPCKLFPR CIPRERSCSA SPCPPGKKCE LREVVCVTAP CWPVRECNPF
NCPPNEEWRD CAAFCEPSCA SPAPLCPDVC KPGRCQCKDT FYRRNGMCVP YVPGCNGVVI
VGPGG
//
