ID   A0A016UM52_9BILA        Unreviewed;       681 AA.
AC   A0A016UM52;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Thrombospondin type 1 domain protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0035.g3051 {ECO:0000313|EMBL:EYC15932.1};
GN   Synonyms=Acey-F09F9.4 {ECO:0000313|EMBL:EYC15932.1};
GN   ORFNames=Y032_0035g3051 {ECO:0000313|EMBL:EYC15932.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC15932.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC15932.1}.
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DR   EMBL; JARK01001371; EYC15932.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UM52; -.
DR   STRING; 53326.A0A016UM52; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR038877; THSD1.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR16311; THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1; 1.
DR   PANTHER; PTHR16311:SF3; THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..681
FT                   /note="Thrombospondin type 1 domain protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001492515"
FT   TRANSMEM        523..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   681 AA;  76460 MW;  0046F6F76145B908 CRC64;
     MVLMSRRHHV FVVISLHFLL FSLIPSVPAA NYSHPESPIS PIIPPNPRSN SRARIHKPGT
     SSQYSIHAAN RSSCRFNTAV IPCECLLEVS DNYFLEEDGE RIAMFAVGPP DIEIRVPAQH
     PMLHELNVEI QPKLCVEEKF AINLLYRPAH VLPDEKWAVV ATHSAVFHTE LFHVIFPCES
     FANAGFYRIA LVNSQDYEIQ HEQWIVVNET AAVQLQLRND SIFPHCTKDF LVRWTTVRCD
     AAMLNYRLRV LAIPEGSTNH EHRSHYIEEI DIARGQTSLS IPCSQFDIFY VKYCFDLVSV
     DTNSSVFHLW RSSCVSTEPA PVVNATWGAW SPWSECSATC GESIQKRYRF CENSDPKRGV
     DCKGELMETK PCKVPDCLAL LNSHPVLANC SCGCAMNGTS GSFFATAADA EFCGGNQTWS
     MAARRNSVVS DFSVATDADA SGKLFFFLGA PYEELVWFSG SNQEKDFTLR LDRPIFVVLW
     YKGNDSDLRQ RKGFTISYST REMPNQYPTR NSLSCHPLCP ETVIIALLSL LFLFIIFFPP
     FVCASLTQRL RRQSCHDRPL IDKVYDSEMV RSGNTEYTQA SGEKPATFTA QRSIGIQLSV
     QSTPRCARTY FPGDSPPPAH GTSISTTDEL EYDYYDGTTI PGSLLAPVSD LLMCEIEIDQ
     IIAQSSLYSK PAETQDVYTQ V
//