ID A0A016UNC4_9BILA Unreviewed; 1621 AA.
AC A0A016UNC4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN Name=Acey_s0033.g2779 {ECO:0000313|EMBL:EYC16675.1};
GN Synonyms=Acey-chs-2 {ECO:0000313|EMBL:EYC16675.1};
GN ORFNames=Y032_0033g2779 {ECO:0000313|EMBL:EYC16675.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC16675.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC16675.1}.
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DR EMBL; JARK01001369; EYC16675.1; -; Genomic_DNA.
DR STRING; 53326.A0A016UNC4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR CDD; cd04190; Chitin_synth_C; 1.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF42; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1086
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1123..1145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1403..1424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 19..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1621 AA; 185592 MW; 177A7FFB8B0DF8B7 CRC64;
METIDKDLAS KGGCYYFTTT DGSRTRPSEA EEAKFRADRT SAQESGQKQQ KQAEFYTSTL
ADHKAWDIFR LLPPKPDKIG HGFWHDASLQ VLKLCTFVVL FLLTLGSAVV AKSSFLLMTS
AIGWGGQNMT ICRDKIPESQ LNTVYITNRL VVKWVWATFL ALSAPEAFCF VRSLHRTLFK
NVKRPTLLQF VVVLIIETLH AIGVGILVFR IFPDLDAVTA TQLTNAMCFV PAILSLLSRR
PSRVAFLLVI VDIVAIAAQS SGFWAFPMFI PSLEKHSVAI PWCLLLISLA WWQNFVHDDS
IFPPVRALAR FASRLSERRS KTYAIVSLWK ICIYFLCMIA FMTSRMKLDD LLQRDPFGEK
LITITGHNLN QTQIDKFLTR MSKFGGADYD ETTPPTTKKP WTSPEGPQVV DAGDYRGARV
RRQPPLDDDD ELPSAFNIYD TYVELNQFTS PYDALWIVLV QVSAVFLCYH SSKFACKVMM
QRLGFALPMA LAVPVTVLVL STTCTFRSED SCHMTNALTK ELFWKCFSSY SSFKVFISSP
QTWIWLGWFI SQCWITVHLW TPEHERLARS EKLFILPYYV GAFVDQSLAF NRRRDDKAKI
RPEDLEFEQE ENSLTYETIP GMGPGNKPPP SVCSLTSSKM ENGLIRDSAS SADAITKIYA
CATMWHETTH EMTCMLKSIF RMDEDQCARR NAQKYLKVID PDYYEFEAHI FFDDAFDVDE
FGDPAINKFV RQFIEVVDQA ASAVHQTQMR LKPPKKVKTP YGGRLQYILP GKNKLTVHLK
DKNKIRHRKR WSQVMYLYYL LGYRLMMKVD EQTRKEVISE NTFILTLDGD VDFTPQCVHL
LVDLMKKNRR LGAACGRIHP RGSGLMVWYQ KFEYAVGHWL QKATEHMIGC VMCSPGCFSL
FRSYALMDDN VTRKYASKSE QPLDYIQYDQ GEDRWLCTLL LQRGYRVEYC AASDALTFAP
EGFNEFFNQR RRWIPSTIAN IIDLLKDYKN VVRVNESISI WYIIYQMVML VSSILGPGTI
FLMIVGAISI SFNIDTNWSL LIVSVPVVTF CIVCLVAKPE KQLLFAQIVS ALFAMLMTAV
FVGTSLQIQK DGILSPHSIF LFSVMGSFVT AAILHPLEFT CIIPGILYFL AIPSMYMLLP
IYSICNLNTV TWGTREDPRP QEKNDLAKPR KSHHMDLVEK GGEGEVDGDW SLGCGSACRL
LCCLKPDKME SSPQVWRINE KLSEISRKLE RIERKQQPGL TRRASIISTD RAAADKHSEV
DEEEQDQSDE PTTNQIAHTR LTRPRFSWLD DKALRRAEIE TIDPEEEHFW LDVIDKYLSP
LTLDPKEQER VRAALVELRN KVVSTFFMVN VVFIIIILVL QLQKDCLHIE WPIGPKYNHT
VRPCHGDTKE EIWVVTRLQL EPLGLVFLIF FMSILIIQFF AMLCHRFGTL AHIIASTELF
CFRKTIGKLS EDELVVQNAV EIARELQAIR GVDESREHEQ MGEQIGRRRV VQNLESSRLS
LMKRKTETLD AAFKKRFFAL SSEVQEPGFS SRDSRRRLTL TKGTIRALEN RRDSLFGTIE
KKDQVPFDFD GGSATASNRG PAQRRLERLF NNPADVHPSD GAKRRTVQQI WDKPDMDSRR
F
//
