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Database: UniProt
Entry: A0A016UNY3_9BILA
LinkDB: A0A016UNY3_9BILA
Original site: A0A016UNY3_9BILA 
ID   A0A016UNY3_9BILA        Unreviewed;      2253 AA.
AC   A0A016UNY3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-JUN-2019, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EYC16557.1};
GN   Name=Acey_s0033.g2720 {ECO:0000313|EMBL:EYC16557.1};
GN   ORFNames=Y032_0033g2720 {ECO:0000313|EMBL:EYC16557.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC16557.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC         Evidence={ECO:0000256|SAAS:SAAS00197451};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYC16557.1}.
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DR   EMBL; JARK01001369; EYC16557.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR013537; AcCoA_COase_cen.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF08326; ACC_central; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00234148};
KW   Biotin {ECO:0000256|SAAS:SAAS00296904};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Ligase {ECO:0000256|SAAS:SAAS00449659};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00234082};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN       66    567       Biotin carboxylation.
FT                                {ECO:0000259|PROSITE:PS50979}.
FT   DOMAIN      223    417       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   DOMAIN     1480   1843       CoA carboxyltransferase N-terminal.
FT                                {ECO:0000259|PROSITE:PS50980}.
FT   DOMAIN     1848   2111       CoA carboxyltransferase C-terminal.
FT                                {ECO:0000259|PROSITE:PS50989}.
FT   REGION        1     24       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A016UNY3}.
FT   COMPBIAS      1     15       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A016UNY3}.
SQ   SEQUENCE   2253 AA;  255174 MW;  527ADC07A58C6F45 CRC64;
     MLTSACRNDS GCVAHSNMSG PERRTIHMSH YQGGTLKDKL DQGDKVFKTV EDFVTTYVED
     PSKRRPIRKM LVATNGIAAV RCILSIRKLL MQLFRNDRII KFICLTTEQE IRSNAEYLKL
     ADHFVFSPGG DNRNNYANVE EIVNHAVEKG VDAVWAGWGH ASENPELPKQ LSARGIVFIG
     PPASAMFSLG DKIASTIIAQ TLDIPTIEWS GSGLKLNLSE RRGHEHVTIT QDLFNQAIVS
     DLYEGLRAVD VHKIGYPLMI KASEGGGGKG IRKCKNEADF KENFVQVQTE VPGSPIFIMK
     CVENARHIEV QLIADRYENV IPVFTRDCSI QRRCQKIIEE APASIAPKET LRRMQEDAVK
     IAKLVGYESA GTVEYMYLPD EDRYFFLELN PRLQVEHPCT EMLASINIPA IQLQIAMGLP
     LNRITDVRLF YGLDRYGTTP LPEELVLTDT EYSVIAARIT SEDPEDFFRP STGSVEVLNF
     RSAQNVWGYF SVSSAGKVHE FADSQFGHLF ARGRTRHEAV SVMLCALQEL ELRASFASQV
     SYLVDMLKEP DFTENRFNTQ WLDNRIANKV LQKAPLPRHE MIAISSAVIG HARVTAAFNN
     FKNAVERGQV IPTKDLTETF LFDLVKDMSI YKVTVTRSGP LNYIITLNGG KTQVEVRLLG
     DGSLLVTHQE RSYTCHLEET SDKFKVTIGR SIVVFEKDND PTILKSPYTG KLLGYKKQNR
     EWVGVGAVYA SVESMKLVFN VEVKKAPGRL EHVAKEGDLL YPGSVIARLV DQKDGEKYKP
     KPFLESFPEW AEFSESERVL PETKRHNNCL DMCMNILNGS IPPGAEFSMK LLVEELFSYL
     ESMTLPHALL KQALNPMVNR IPEKFSSKMK DAMKNDSMQN FATIKSILDE YFGTLSHTEW
     ETAKAVCNTV YHICERFENG VLSNTSYVLN SLLAEYKQCE RFFEGRVYDD AVALLNEEFG
     SDKDRVVAMI YSHTQLKGKN KFMLALLEAV ERRGMHLVTP LMDNLREIGN MFHTDEVCNQ
     ARQLLLQNSR IKYRKFLNKI VWDIEKVNLA DRDNKEVLPV KEAVTKLRGL FEQMMDSGMT
     PKDMFNTSPW AHKAIHEFFF DEKLADFAIR AYIGLHFAVD DVTCTALPCA NQDAKVYDFF
     VDNSNLVHYM ISPSVESNQY LSIVKLSVNR DNFMQAITHE NLIDSLVSKF SECGIKSNGI
     RSQLRVTLLV NVIQPATPSQ SKQGHREAQL EELPEHSDYD DQIVAEAENA SQIIRSALAE
     KLTAVDILTH VLVCNSCKPL TQVDLLGSER LELWRLPSEA RLVSDRLSNL NVFKYDDPDK
     RFSRLFVREM LEIPIRTVED SFEEIGNTVS AQLDSACGAI NVAMRKFKKN IYVSNHVFLY
     VTFPKMLPTF TTDYQDDLDA LFEEAIKEQR EVLYKHHVTE VEIVYTKLSA NGEVRQLWKR
     RVKFLDETGV TPEFGIYDEH KTVIYPRKLS HLLYANKLAA HSKIKKIEKK RSSTRANGTT
     YVYDYPTLIG RACLEEWKKL QDRSETNKEG LDLFQRQFAQ LTPVQRAAYH NGDYRQFFTE
     EELVVKNDEV VRISDKDELK KRADNCNNES GMVAWQLRLF TPEKPLGYTI IAIANDITFQ
     SGSFATPEDM LYSLASEYSR KHKFPRVNVS CNSGARIGLC EDVSKVFRAK FKDPNHPEEG
     FEYLYVDGCE EESLKGQIVY EKMPNGLLRL KAVVGKQNEN IGVENLQGSG MIAGETSAAY
     DEVPTYCLVT GRTVGIGAYT ARLAHRIVQT RSSHLILTGA PALNTLLGKE VYTSNNQLGG
     IQIMFKNGVT HAVVNDDFEG ICKIIQWMSY LPDETTSFPY RRSIGFDSAP RPVEFTIEPN
     KPYDIRQLID SGDATDIHGI CDSNSFDEIM NDWAKTIIAG RARIGGIPIG VVSSELRNVM
     SVSPADPASP NSQSVEVHQA GQVWYPDSAF KTAEVIGDFN REGLPLLFIA SLRGFSGGQR
     DMFEMVLKFG AQIVDALRIY RMPVIIYIPC QGELRGGAWV VLDSKINPGF ISMVADKESR
     GGILEANAII GIKFRDDKLL ALQKRNDEIM QQLDARLLEQ VKLYGAESAE ANHARTLITR
     RSEELKKSYR GVTVEFADLH DRAERMSIKK AVQHVTDLAN SRNLFTQIFR LETAKVHLCE
     IYLDRADRHT TRQEAYKWVA SRFADFHQGV LSLPPSEQMV ILEKFVASGT FSRLVDQVRE
     ESVERELLMM SEKELRDMKR LLERCAAKRK LSW
//
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