ID A0A016UP55_9BILA Unreviewed; 807 AA.
AC A0A016UP55;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN Name=Acey_s0034.g2894 {ECO:0000313|EMBL:EYC16268.1};
GN Synonyms=Acey-pro-3 {ECO:0000313|EMBL:EYC16268.1};
GN ORFNames=Y032_0034g2894 {ECO:0000313|EMBL:EYC16268.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC16268.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU365057}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC ECO:0000256|RuleBase:RU365057}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC16268.1}.
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DR EMBL; JARK01001370; EYC16268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UP55; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365057};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU365057};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT DOMAIN 100..471
FT /note="SDA1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08158"
FT DOMAIN 580..741
FT /note="SDA1 middle"
FT /evidence="ECO:0000259|Pfam:PF05285"
FT DOMAIN 759..802
FT /note="SDA1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21638"
FT REGION 265..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..621
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 93357 MW; 8194F752F396A5FE CRC64;
MKISLLKLAI PIISPDFILV DIQSFQVIMA SAAAPLRNSR YTMSERNLGL MMEIIRKDPE
SYREEFLEQF DHYLHTMKLL HLQPQQHRME LQPLLESITF LSGLAKHYPE QAKEFSAHMV
TVLREQGCGL DPHVRMSFCK ALVLLRNQDL LDPMEFIDIF FELVKVEDKQ LRKFILGSIS
SLLKRLYTQK KNMKLLGKIQ NFCFAKMKDS RAIVARAAQL ICIDAFRKKY WRDAKCANVI
AEACFHKVPK IQVTAMKFFL GSKKDEDGES DVSDDESESE DERKTIKEVM TAFRHAKKTR
KRAKDLERSK KAINKKKKAK KEGRSKECNL LAIQLLYDPQ EFADKLFRML ESKKIDKYEV
RLFRIALCAR VIGVHRLHTL SFYSYLHRYL QPKQRDVTRI LLYAAQACHE MVPPDTVEQL
VRTIANNFVT DRNSPEAITV GINAIREILA NCPFAATEEL LRDLAEYKTY KNKNVSMAAR
ALITLFRAVN PRLLARKDRG RPTDGEEEKE FVAFAKPAVA EFVPGAEILE EHREENGGME
VDDVEDSDDS IDISDVDTDE VDSDDDGPPA KKKLEESGEW EEVNDEDDDE EMDDEGWETD
DGDEEEDEDE DEEDEDEGAG SDNDANMTHE ESGPSKEQSG EGEQDPKKKA ELISTDRILT
QEEFKQIRIY QLKKKLIGEK RLKKQLGNNR KNDDVRLIEE LGERMERRGD GDGLPRLKDI
EQFHKKRKQT KEERMADIKD GRDEDQKFGR PKKNGPHVGR TNRELAKKKV FSMVKAKVRG
KNRQRSFRDQ QKSLRNYLLR QSGRKPQ
//
