ID   A0A016UT61_9BILA        Unreviewed;       233 AA.
AC   A0A016UT61;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=TIL domain-containing protein {ECO:0000259|Pfam:PF01826};
GN   Name=Acey_s0027.g1606 {ECO:0000313|EMBL:EYC18599.1};
GN   ORFNames=Y032_0027g1606 {ECO:0000313|EMBL:EYC18599.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC18599.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC18599.1}.
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DR   EMBL; JARK01001363; EYC18599.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UT61; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd19941; TIL; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   Pfam; PF01826; TIL; 1.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 1.
PE   4: Predicted;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..233
FT                   /note="TIL domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001492689"
FT   DOMAIN          155..216
FT                   /note="TIL"
FT                   /evidence="ECO:0000259|Pfam:PF01826"
SQ   SEQUENCE   233 AA;  26055 MW;  EF85701FCB73CECF CRC64;
     MRSVILFAVL ALNAYASPFE CGENGKCAPG LKCEDKTCVL RTDCPMMSMP RLKAGCKMEM
     EVDERDCPMP KIVCDKKNLK CGSIFCEPGY ECDDNTLKCI PRTDCPSIAL PEQEGCTDKM
     ILDEFDCLVP VRTCKPEKPL RQRRETSSTK ASVKCPKNAE WRECTNICPE KSCENYLQTS
     TCFSLRCGEP GCMCKEGHVL LSSANKENGC VRRETCVKLD SMKKDIEKNK PAN
//