ID A0A016UX13_9BILA Unreviewed; 455 AA.
AC A0A016UX13;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Neurotransmitter-gated ion-channel ligand-binding domain-containing protein {ECO:0000259|Pfam:PF02931};
GN Name=Acey_s0024.g907 {ECO:0000313|EMBL:EYC19516.1};
GN Synonyms=Acey-lgc-20 {ECO:0000313|EMBL:EYC19516.1};
GN ORFNames=Y032_0024g907 {ECO:0000313|EMBL:EYC19516.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19516.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC19516.1}.
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DR EMBL; JARK01001360; EYC19516.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UX13; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR PANTHER; PTHR18945:SF582; NEUR_CHAN_LBD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..455
FT /note="Neurotransmitter-gated ion-channel ligand-binding
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001488763"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..222
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 455 AA; 51925 MW; 2FA2477F4482C375 CRC64;
MLALCCCWII LGIVVGKVAA SIPMIAANAD ECDSLKNSSK GFLEMTTHQR ERLENCVFTF
LTDEEMKFNR DPNSFHTDPP PEAKLTIQVD DVAIRHVQLT SGSTYQFQIY GDIYLTWEDT
RLKWDSSEWK VENFYIHDSH KIWSPHLIDH SICTDPSTCS SELTDVEIVS EGRAYARLAF
RYSAYCNVDY SRFPEDQNHC CIYFTAFEAD RDVAFALETD HSKKVNRPVA AQNLYDRVRG
LSTLADEHSA WVVDEHTVDI THLAGISSLE VLKVCVHAEK KMSTIRMALK IPVTIATLIM
LVSPLFGDLR TQVYIKLFIL ALQTICFIYL CSIAPPNGFA GMRPKLYTYY ELIFVMSAIS
LLMTLVCVAL SRVKRTIAPT HRFYLAAKLV NRVVCCIEPD QATSYQRYLE DADNQRTSNE
PDATMEWRHV YLAVNNTVSG AFFSMYLIII LIYFF
//
