ID   A0A016UZG2_9BILA        Unreviewed;       686 AA.
AC   A0A016UZG2;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0023.g758 {ECO:0000313|EMBL:EYC19863.1};
GN   ORFNames=Y032_0023g758 {ECO:0000313|EMBL:EYC19863.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19863.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC19863.1}.
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DR   EMBL; JARK01001359; EYC19863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UZG2; -.
DR   STRING; 53326.A0A016UZG2; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR46238; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46238:SF8; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          244..500
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          661..686
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  79424 MW;  468E51C1CA4E71E4 CRC64;
     MRTGPNRRLK EKEESVTSRI KLPPVTTIDE TWENATRAVV EVARSELGTT KPGRRKIDRQ
     TWLWTDEVKI KVREMKRLYH VFLGDKTVDN WWQYLIAKKA AKKAVAATKA AHYDNISKQL
     DAKDGGERLI YRLARSRQRQ TEDVEKFYGV NDEHGQLITD RKKATKRWCD YFEKISTEEF
     SHPPIPQLPP TCGPIQPITV EETMAALKRI KPGKATGSDD VAAELWKSRH WNNSAEWLTA
     FFNKVVGEKK TPVDWQRSTT IPIWKRKGNP ADCANYRPIR LLSHSMKIFE RIIDRRIRDI
     IRVSTNQCGF VANCGTTDAI HAARLLIEKH REKQKPLHLA FVDLEKAFDR VPHEAIWYAL
     RWHGVAEELI EWVRILYADP RSRVQAAAGT SAEFPISVGV HQGSALSPLL FVMDALTRDL
     QRPAPWTLLY ADDVMLASQQ KEDLQRQTQA WSERLDRFGL RLNVKKTEYM TTNPDELSTI
     HVDGNDLRRT NYFKYLGSTL SADDNLAHEV VARVNRTWLK WRSMTGVLCD KNIPDRFTSK
     VYRAVVRSVA LYGAECWPAT KKVERRLSAM ETKMLRWTTG VTRADRIRNE KIRERFGIAP
     IADKLRETRL RWYGDVLRAN EDTLCKVGLD LEVPGKRPKG RPKQRWLDTL HADLKHVGVH
     PDQAHDRVKW RQKIRKADPA TKRDES
//