ID A0A016V0Q0_9BILA Unreviewed; 727 AA.
AC A0A016V0Q0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=NOT2/NOT3/NOT5 C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0021.g454 {ECO:0000313|EMBL:EYC20836.1};
GN Synonyms=Acey-ntl-3 {ECO:0000313|EMBL:EYC20836.1};
GN ORFNames=Y032_0021g454 {ECO:0000313|EMBL:EYC20836.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC20836.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005290}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682, ECO:0000256|PIRNR:PIRNR005290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC20836.1}.
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DR EMBL; JARK01001357; EYC20836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V0Q0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-UniRule.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:UniProt.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005290};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005290};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR005290};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR005290}.
FT DOMAIN 4..237
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 596..721
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 92..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 22..61
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 153..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 80352 MW; 86EBC6AE654DB2E5 CRC64;
MAEKRKLLAE IDKCFKKIDE GVELFEETMK KMQEANSDNQ REKYQDDLKK EIKKLQRLRD
QVKGWQNCSE IKDKDKLTHY RKIIEQRMEQ FKDIERENKT KPHSKQGLSA EEKLDPREKE
KVETIEWLQS QIRELSDEAD RTESQIESIS SLDAGKRRGK KEDGKKGEKE KRMEELKRHL
DRMKFHIGKL EVCMRMVNNE SLESKRVMEV LKDPLEMYVD ALVDPDYEGD TEHLENLDPE
DAYEELDLGA LSAQIGGIQI GSLDEEKENG HDNGSTHEAS GGDDGNSRSG GSRHGSQDTP
ASPAPRRTVA AASVPVTPAK LAKDGSVEAG QLGSLSGVNQ ATPPPPPPGI PYNSVAAGRI
AASSSVTNTS GSATSPATNV VNAKTTVIAT RPGANSSGGV QLVQLVTSTS TQPNSTSAQD
DDAGSTISSQ NEGGATSTAD NVVNKPDESR TSTVPQPAAT KPLATANGAA AENPSLNTPT
ETTAQHFAFT NELYAANEAS AALSADGSTA SAMADVVEGV QRAPGESGSS RRSGDVGLDA
ADDPLRVLRL SQQNQQPANT EPQRAHIPAW LGASPLGRIQ TTNEMEMQLA ALEASLARTP
LPMDSERPRT YLPKIPCPCA SYYPQVSAQN VDTLEYYLRL SPETLFFIFY YMEGTRAQLL
AAKALKKLSW RFHTKYLTWF QRHEEPKQIT DDFEQGTYVY FDYEKWSQRK KESFTFEYRY
LEDKDFE
//
