ID A0A016V4Q8_9BILA Unreviewed; 841 AA.
AC A0A016V4Q8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN Name=Acey_s0018.g3494 {ECO:0000313|EMBL:EYC21713.1};
GN ORFNames=Y032_0018g3494 {ECO:0000313|EMBL:EYC21713.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC21713.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC21713.1}.
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DR EMBL; JARK01001354; EYC21713.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V4Q8; -.
DR STRING; 53326.A0A016V4Q8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 481..747
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 841 AA; 96960 MW; D555BA96947624A4 CRC64;
MNLGTYNVRT LNSEAALSFL FDELHNIKID IVAVCETRRR KDMSVKWNDG SEVMLGAAKN
GVGGVGFIVL PSVTSRIISM EIVSHRLAIL KLRIGKSSTM KVVAVYAPTS AASDDEIEEF
YEELHRHLRQ KSTYTLVLGD FNAKLGSGHS EDTFIGKFGY GARNERGQRL ADFAECTKLY
VMNTFFQKRP GRRWTWRAPN DRTRNEIDFV LCDKKRIVKD VSVIAESKVC VHSDHRLIRA
KVVVDLREER RRLARASQRR KPQQFSEALF TRAVENTDWS MCVEDIDEDY GSILEKLQKC
RSLATVRREG QCRKRLTEAT LQMLSDRRKM ANAGNTGLEY KILCKELRRR MADDYENFRK
ERLRKAAEDR ASLKKAWREV QVCRKMPTAL VNEQGRRTTV RKEMEEICQN YFNALFASTK
SIAPPSIERI ERVPEVLSAE IEKAVRQMKP GKAVGPDETR AEEIRAGGEV LAKALSIRFT
KYINTGRIPE QWKHARTVLI PKKGDREDIR NYRPITLLSH LYKIFMRVIY ARMERTLDDN
MPREQAGFRR RFSTIDHIFT ISQLTERCRE YKLPLCLLFV DFEKAFDSVE HNAVLRAMTD
QGVEAAYVRI LQETMRESHT EITLFERPLK IYMKRGVKQG DICSPKAFTC ALQSVMRQVA
EKDGFEIDGE TLQMLLFADD VVLIASKPET LQSLLNEMCH LTESIGLKIH PGKTKWMKNA
HCDDFEIKLN NQLVERVEHY VYLGQAIRMD NDLRLELSRR RKAGWTAFSK IDVLLKNKDI
PAQTKSQLFH SSVLPALLYG CETWNLTKAE ERSLQVTQRA MERQMLGISR GKNRGQGTSP
E
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