ID   A0A016V7R8_9BILA        Unreviewed;      1173 AA.
AC   A0A016V7R8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Ground-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0015.g2794 {ECO:0000313|EMBL:EYC23704.1};
GN   ORFNames=Y032_0015g2794 {ECO:0000313|EMBL:EYC23704.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC23704.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC23704.1}.
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DR   EMBL; JARK01001351; EYC23704.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016V7R8; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd00081; Hint; 1.
DR   Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR   InterPro; IPR007284; Ground-like_dom.
DR   InterPro; IPR001657; Hedgehog.
DR   InterPro; IPR001767; Hedgehog_Hint.
DR   InterPro; IPR003586; Hint_dom_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR006141; Intein_N.
DR   PANTHER; PTHR46706:SF7; GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED; 1.
DR   PANTHER; PTHR46706; PROTEIN QUA-1-RELATED; 1.
DR   Pfam; PF04155; Ground-like; 4.
DR   Pfam; PF01079; Hint; 1.
DR   PRINTS; PR00632; SONICHHOG.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          966..1077
FT                   /note="Hint"
FT                   /evidence="ECO:0000259|SMART:SM00306"
FT   DOMAIN          1078..1122
FT                   /note="Hint"
FT                   /evidence="ECO:0000259|SMART:SM00305"
FT   REGION          217..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  126210 MW;  99A5950908259F35 CRC64;
     MTTHPNSIHA LFHVICKDRR KTHPKRHSRV LDMLTGLFRY LLCLIVVIQL VHPNFNDNCT
     SSSCHDRTNT TAKLTIGRTK RAAPAQCSSS SDDVAHSLVS SVCCDSMIPL FIDNQLSTTD
     GIGAITRAVQ QRVQSQFNRS FEVIISESDF VVNTYYSGPR QCKFETDRYF VALYETPVQY
     DLADTATENF VASIDSRDPL GWKQAPLAED NEALPVEGTA GTESQLTAPS SAEGAFAIGG
     PEEGGPAEAG PAAALPAAAG PAVGGPAVGG PAAAGPAAAG SAAGAAAGVA QPSQAGQAGS
     GGVCSWRSGA ADPNIPYVFS ADECCDARLN TIMRDAAARS RDTPHLGDSA KYIQRRIQLE
     YGLSFEVMMS RGDFAVSSYY HGPSNCKIND GVFHYVAYAT PVQYDPFNIA QEDYLASTDA
     EEPLGSTRYT NLRGDRPDIR VEPSAGEDIS IQPAILAARA SLYEGAGGAG RTANREPGAP
     TSGFFPEDAS LLTASAIDGF HVGGNRSLGT VISQEGGDLP PGTHCDKEDR TGDKCCSGLL
     FETMTDAFYE LSSSPQFAFT SAGNIASLIQ KRAQLRFDQS FEVIVSPGDF ALASHGFGDQ
     TCKYKERGFT AIAYATPRQY DITQTAAESY YSSISSRDNL GATQPFLPGQ RAFHTPLQVY
     GEGAGAGLPV GSHCTDSRAG SKCCNAQLFN VMQSAYDSVI SRNDFNPYDM RLIARTIQFN
     VEEQLQMSFE TIVSTDDFAF SSDYSGNDVC KYRIDRYYVM TYATPVQYPI HSQFYEDSGP
     AIPINCPAEL DALDGAVCCD GTLQYEMTRA IDEAIINQPE GQRNSDALAR RRFGTTFETI
     VSRSDFTWQT HIYNENTCKI DTRGYHTLTV ESSKAPIQSA MGQPPVPPQF PPPQGPFPPA
     FVGPPAAAPP VAAPPVAAPP VAAPPVAAPP VAAPPVVPPA FAPPPVVPGF GGGAGAGAGG
     GGGGGGACFS TDTWVTTPNG KKRMDQLKVG DFVLTANLTT AYFAPMSLWI HREPDVITKF
     VTIMTDYGKM LALTPRHLIF RNKCDEYYDD RVDSLPSNSQ AVYADELKVG DCVYLLYRNG
     FRQQKLQDIS ITQRRGIFSP LTPNGRIIVN DMLASCYSDV NEATLQTTYF SAMHSLRKRV
     LTWFGSWIDQ TVDLPFGSEF SMELLRLIVP YVK
//